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Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Overview of attention for article published in International Journal of Nanomedicine, October 2017
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About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

Mentioned by

twitter
2 tweeters

Citations

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28 Dimensions

Readers on

mendeley
47 Mendeley
Title
Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy
Published in
International Journal of Nanomedicine, October 2017
DOI 10.2147/ijn.s145012
Pubmed ID
Authors

Maobin Xie, Dejun Fan, Yi Li, Xiaowen He, Xiaoming Chen, Yufeng Chen, Jixiang Zhu, Guibin Xu, Xiaojian Wu, Ping Lan

Abstract

To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Curcumin (CM)-silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS. CM-SF NPs had a time-dependent intracellular uptake ability, which led to an improved inhibition effect on colon cancer cells. Interestingly, the anticancer effect of CM-SF NPs was improved, while the side effect on normal human colon mucosal epithelial cells was reduced by a concentration of ~10 μg/mL. The anticancer mechanism involves cell-cycle arrest in the G0/G1 and G2/M phases in association with inducing apoptotic cells. The natural compound-loaded SF nanoplatform prepared by SEDS indicates promising colon cancer-therapy potential.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 21%
Student > Master 7 15%
Professor 2 4%
Student > Doctoral Student 1 2%
Student > Bachelor 1 2%
Other 5 11%
Unknown 21 45%
Readers by discipline Count As %
Engineering 6 13%
Biochemistry, Genetics and Molecular Biology 5 11%
Materials Science 3 6%
Agricultural and Biological Sciences 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 7 15%
Unknown 22 47%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2022.
All research outputs
#13,373,892
of 21,454,959 outputs
Outputs from International Journal of Nanomedicine
#1,548
of 3,588 outputs
Outputs of similar age
#183,513
of 339,245 outputs
Outputs of similar age from International Journal of Nanomedicine
#20
of 62 outputs
Altmetric has tracked 21,454,959 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,588 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,245 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.