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| Title |
Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy
|
|---|---|
| Published in |
International Journal of Nanomedicine, October 2017
|
| DOI | 10.2147/ijn.s145012 |
| Pubmed ID | |
| Authors |
Maobin Xie, Dejun Fan, Yi Li, Xiaowen He, Xiaoming Chen, Yufeng Chen, Jixiang Zhu, Guibin Xu, Xiaojian Wu, Ping Lan |
| Abstract |
To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Curcumin (CM)-silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS. CM-SF NPs had a time-dependent intracellular uptake ability, which led to an improved inhibition effect on colon cancer cells. Interestingly, the anticancer effect of CM-SF NPs was improved, while the side effect on normal human colon mucosal epithelial cells was reduced by a concentration of ~10 μg/mL. The anticancer mechanism involves cell-cycle arrest in the G0/G1 and G2/M phases in association with inducing apoptotic cells. The natural compound-loaded SF nanoplatform prepared by SEDS indicates promising colon cancer-therapy potential. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Malaysia | 1 | 50% |
| Canada | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 23% |
| Student > Master | 7 | 13% |
| Student > Bachelor | 2 | 4% |
| Professor | 2 | 4% |
| Student > Doctoral Student | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 24 | 46% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 6 | 12% |
| Chemistry | 3 | 6% |
| Materials Science | 3 | 6% |
| Agricultural and Biological Sciences | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 25 | 48% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2023.
All research outputs
#7,050,597
of 25,382,440 outputs
Outputs from International Journal of Nanomedicine
#734
of 4,122 outputs
Outputs of similar age
#104,701
of 331,218 outputs
Outputs of similar age from International Journal of Nanomedicine
#14
of 91 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,218 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.