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Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

Overview of attention for article published in International Journal of Nanomedicine, November 2017
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Title
Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
Published in
International Journal of Nanomedicine, November 2017
DOI 10.2147/ijn.s143733
Pubmed ID
Authors

Feng Li, Yan Chen, Shubo Liu, Jian Qi, Weiying Wang, Chenhua Wang, Ruiyue Zhong, Zhijun Chen, Xiaoming Li, Yuanzhou Guan, Wei Kong, Yong Zhang

Abstract

Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, the fabrication of size-controlled zein particles has been a challenging issue. In this study, a modified anti-solvent precipitation method was developed, and the effects of various factors, such as mixing method, solvent/anti-solvent ratio, temperature, zein concentrations and the presence of sodium caseinate (SC) on properties of zein particles were investigated. Evidence is presented that, among the previously mentioned factors, the mixing method, especially mixing rate, could be used as an effective parameter to control the size of zein particles without changing other parameters. Moreover, through fine-tuning the mixing rate together with zein concentration, particles with sizes ranging from nanometers to micrometers and low polydispersity index values could be easily obtained. Based on the size-controlled fabrication method, SC-coated zein nanoparticles could also be obtained in a size-controlled manner by incubation of the coating material with the already-formed zein particles. The resultant nanoparticles showed better performance in both drug loading and controlled release, compared with zein/SC hybrid nanoparticles fabricated by adding aqueous ethanol solution to SC solution. The possible mechanisms of the nanoprecipitation process and self-assembly formation of these nanoparticles are discussed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 64 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 17%
Student > Bachelor 9 14%
Student > Master 8 13%
Other 4 6%
Researcher 4 6%
Other 8 13%
Unknown 20 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 16%
Pharmacology, Toxicology and Pharmaceutical Science 10 16%
Chemistry 6 9%
Biochemistry, Genetics and Molecular Biology 5 8%
Chemical Engineering 3 5%
Other 7 11%
Unknown 23 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 November 2017.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from International Journal of Nanomedicine
#2,470
of 4,122 outputs
Outputs of similar age
#217,828
of 340,752 outputs
Outputs of similar age from International Journal of Nanomedicine
#45
of 84 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,752 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.