Title |
Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder
|
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Published in |
Pharmacogenomics and Personalized Medicine, November 2014
|
DOI | 10.2147/pgpm.s52844 |
Pubmed ID | |
Authors |
Florence Levy |
Abstract |
This review examines molecular genetic studies shown to be of importance in the etiology of attention-deficit/hyperactivity disorder (ADHD) and contrasts prefrontal versus sub-cortical mechanisms. Although these mechanisms are not completely dissociated, an understanding of prefrontal dopaminergic/noradrenergic versus subcortical D1/D2 receptor mechanisms is useful for studies of diagnosis versus potential adverse effects. Dopamine physiology, dopamine receptor studies, alpha-2 agonist studies, and dopamine transporter and potential new therapies are reviewed. Further understandings of molecular mechanisms involved in etiology versus treatment and adverse effects should help personalize the treatment of ADHD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
South Africa | 1 | 3% |
Unknown | 34 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 22% |
Student > Master | 5 | 14% |
Student > Bachelor | 4 | 11% |
Other | 4 | 11% |
Student > Ph. D. Student | 3 | 8% |
Other | 8 | 22% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 19% |
Medicine and Dentistry | 6 | 17% |
Neuroscience | 4 | 11% |
Psychology | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Other | 6 | 17% |
Unknown | 6 | 17% |