Title |
Severe agitation in severe early-onset Alzheimer’s disease resolves with ECT
|
---|---|
Published in |
Neuropsychiatric Disease and Treatment, November 2014
|
DOI | 10.2147/ndt.s71008 |
Pubmed ID | |
Authors |
Suna Su Aksay, Lucrezia Hausner, Lutz Frölich, Alexander Sartorius |
Abstract |
Dementia-related behavioral disturbances are mostly treated with antipsychotics; however, the observed beneficial effects are modest and the risk of serious adverse effects high. We report the case of a 57-year-old woman with severe early-onset Alzheimer's disease and severe agitation, whom we treated with electroconvulsive therapy (ECT). A significant clinical improvement was achieved over eight ECT sessions, which were tolerated well without cognitive worsening, and lasted approximately 3 months. Our case demonstrates the safe and effective use of ECT in pharmacotherapy-resistant severe agitation in Alzheimer's disease. The risk-benefit profile of ECT for dementia-related agitation should be further investigated in clinical trials. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
United States | 1 | 2% |
Unknown | 61 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 16% |
Student > Ph. D. Student | 9 | 14% |
Student > Master | 9 | 14% |
Student > Doctoral Student | 7 | 11% |
Student > Bachelor | 5 | 8% |
Other | 11 | 17% |
Unknown | 12 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 13 | 21% |
Medicine and Dentistry | 13 | 21% |
Nursing and Health Professions | 6 | 10% |
Linguistics | 4 | 6% |
Neuroscience | 4 | 6% |
Other | 9 | 14% |
Unknown | 14 | 22% |