| Title |
Fentanyl-induced respiratory depression is attenuated in pregnant patients
|
|---|---|
| Published in |
Drug Design, Development and Therapy, November 2017
|
| DOI | 10.2147/dddt.s147304 |
| Pubmed ID | |
| Authors |
Xiaofei Cao, Shijiang Liu, Jie Sun, Min Yu, Yin Fang, Zhengnian Ding |
| Abstract |
Respiratory depression is a complication of intravenous fentanyl administration. The effect of pregnancy on respiratory depression following opioid administration is unclear. This study investigated the effect of pregnancy on fentanyl-induced respiratory depression. Female patients were divided into three groups (n=20 per group): control group (non-pregnant and scheduled for laparoscopic surgery), early pregnancy group (pregnant for 45-60 days and scheduled for abortion), and postpartum group (5-7 days postpartum scheduled for complete curettage of uterine cavity). All patients received an intravenous infusion of fentanyl 2 μg/kg. Respiratory rate (RR), end-tidal pressure of carbon dioxide (PETCO2), and pulse oxygen saturation (SpO2) were recorded continuously from just before fentanyl infusion to 15 min after commencing infusion. Plasma levels of progesterone were measured. SpO2 levels in the early pregnancy and postpartum groups were significantly higher and the levels of RR and PETCO2 were significantly lower than the control group. RR and SpO2 levels were significantly decreased in all groups, whereas PETCO2 was significantly increased after fentanyl infusion. The rates of RR increase and SpO2 decrease were significantly faster in the control group than in the other groups. The lowest SpO2 after intravenous fentanyl administration was significantly positively correlated with plasma progesterone levels. Pregnancy improves fentanyl-induced respiratory depression, which may be associated with the increased levels of plasma progesterone. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 9% |
| Student > Ph. D. Student | 4 | 9% |
| Student > Bachelor | 4 | 9% |
| Lecturer | 2 | 4% |
| Librarian | 2 | 4% |
| Other | 9 | 20% |
| Unknown | 20 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 7 | 16% |
| Medicine and Dentistry | 7 | 16% |
| Neuroscience | 4 | 9% |
| Psychology | 3 | 7% |
| Environmental Science | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 20 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2017.
All research outputs
#16,868,837
of 25,584,565 outputs
Outputs from Drug Design, Development and Therapy
#1,010
of 2,254 outputs
Outputs of similar age
#207,163
of 341,375 outputs
Outputs of similar age from Drug Design, Development and Therapy
#20
of 46 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,254 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.3. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,375 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.