| Title |
Mesenchymal phenotype of circulating tumor cells is associated with distant metastasis in breast cancer patients
|
|---|---|
| Published in |
Cancer Management and Research, November 2017
|
| DOI | 10.2147/cmar.s149801 |
| Pubmed ID | |
| Authors |
Shirong Zhang, Tiecheng Wu, Xinguo Peng, Jian Liu, Fang Liu, Shiyang Wu, Suyan Liu, Yan Dong, Shujun Xie, Shenglin Ma |
| Abstract |
In this study, we investigated the relationship between the epithelial-mesenchymal transition phenotype of circulating tumor cells (CTCs) and distant metastasis in breast cancer patients. We analyzed the expression of epithelial (epithelial cell adhesion molecule, cytokeratin [CK]8, CK18 and CK19) and mesenchymal (vimentin and TWIST1) markers in CTCs from a large cohort of Chinese breast cancer patients (N=1083) using Canpatrol™ CTC assays. We identified CTCs in 84.9% (920/1083) of the breast cancer patients enrolled in this study. Among these 920 patients, 547 showed epithelial CTCs, 793 showed biphenotypic CTCs and 516 showed mesenchymal CTCs. Receiver operating characteristic (ROC) curves demonstrated circulation of both biphenotypic and mesenchymal CTCs (area under ROC curve value: 0.728; sensitivity: 68.7% and specificity: 71.6%) in patients was associated with distant metastasis. These findings demonstrate that the epithelial-mesenchymal transition phenotype of CTCs is a potential biomarker predictive of distant metastasis in breast cancer. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 75% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 24% |
| Researcher | 5 | 15% |
| Student > Ph. D. Student | 5 | 15% |
| Student > Postgraduate | 2 | 6% |
| Lecturer | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 12 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 24% |
| Medicine and Dentistry | 3 | 9% |
| Engineering | 3 | 9% |
| Agricultural and Biological Sciences | 3 | 9% |
| Chemistry | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 13 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2017.
All research outputs
#8,343,963
of 25,584,565 outputs
Outputs from Cancer Management and Research
#376
of 2,067 outputs
Outputs of similar age
#127,107
of 341,375 outputs
Outputs of similar age from Cancer Management and Research
#7
of 32 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 2,067 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,375 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.