| Title |
Association between the IL-6 gene polymorphism and tuberculosis risk: a meta-analysis
|
|---|---|
| Published in |
Infection and Drug Resistance, November 2017
|
| DOI | 10.2147/idr.s144296 |
| Pubmed ID | |
| Authors |
Hao Wang, Caishuang Pang, Ni Zeng, Chun Wan, Yongchun Shen, Fuqiang Wen |
| Abstract |
The gene polymorphism of interleukin-6 (IL-6) has been shown to be implicated in tuberculosis susceptibility in many studies, but with conflicting results. This study aimed to provide more accurate estimation of the relationship between IL-6 gene polymorphism and tuberculosis risk through a meta-analysis. A literature search was performed in PubMed, EMBASE, and other databases. Data were retrieved, and pooled odds ratio (OR) with 95% CI were calculated. Statistical analyses were performed by using STATA 12.0. Twelve publications with 2635 cases and 3049 controls were included. The pooled analysis demonstrated significant evidence of association between IL-6 (-174G/C) and low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.693, 95% CI 0.581-0.826, p<0.001). Subgroup analysis got similar results for IL-6 (-174G/C) in Asians and Latinos, but the significance did not exist in Caucasians. IL-6 (-572C/G) polymorphism was also associated with low risk of tuberculosis in dominant model (CC+GC vs GG: OR =0.719, 95% CI 0.577-0.896, p=0.003). No publication bias was detected in either of the polymorphisms. In summary, IL-6 -572 C/G polymorphism may be associated with a decreased risk of tuberculosis, and C allele is the protective factor against tuberculosis for IL-6 -174G/C among Asians and Latinos, but not in Caucasian population. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 30% |
| Student > Master | 3 | 15% |
| Student > Ph. D. Student | 2 | 10% |
| Researcher | 2 | 10% |
| Professor | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 5 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 5 | 25% |
| Biochemistry, Genetics and Molecular Biology | 3 | 15% |
| Nursing and Health Professions | 2 | 10% |
| Arts and Humanities | 1 | 5% |
| Agricultural and Biological Sciences | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 7 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2017.
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#18,576,855
of 23,008,860 outputs
Outputs from Infection and Drug Resistance
#1,043
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#252,100
of 329,172 outputs
Outputs of similar age from Infection and Drug Resistance
#18
of 21 outputs
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