↓ Skip to main content

Dove Medical Press

Article Metrics

Autophagic flux induced by graphene oxide has a neuroprotective effect against human prion protein fragments

Overview of attention for article published in International Journal of Nanomedicine, November 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

twitter
14 tweeters

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
10 Mendeley
Title
Autophagic flux induced by graphene oxide has a neuroprotective effect against human prion protein fragments
Published in
International Journal of Nanomedicine, November 2017
DOI 10.2147/ijn.s146398
Pubmed ID
Authors

Jae-Kyo Jeong, You-Jin Lee, Seung Yol Jeong, Sooyeon Jeong, Geon-Woong Lee, Sang-Youel Park

Abstract

Graphene oxide (GO) is a nanomaterial with newly developing biological applications. Autophagy is an intracellular degradation system that has been associated with the progression of neurodegenerative disorders. Although induction of autophagic flux by GO has been reported, the underlying signaling pathway in neurodegenerative disorders and how this is involved in neuroprotection remain obscure. We show that GO itself activates autophagic flux in neuronal cells and confers a neuroprotective effect against prion protein (PrP) (106-126)-mediated neurotoxicity. GO can be detected in SK-N-SH neuronal cells, where it triggers autophagic flux signaling. GO-induced autophagic flux prevented PrP (106-126)-induced neurotoxicity in SK-N-SH cells. Moreover, inactivation of autophagic flux blocked GO-induced neuroprotection against prion-mediated mitochondrial neurotoxicity. This is the first study to demonstrate that GO regulates autophagic flux in neuronal cells, and that activation of autophagic flux signals, induced by GO, plays a neuroprotective role against prion-mediated mitochondrial neurotoxicity. These results suggest that the nanomaterial GO may be used to activate autophagic flux and could be used in neuroprotective strategies for treatment of neurodegenerative disorders, including prion diseases.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 30%
Student > Doctoral Student 2 20%
Researcher 2 20%
Student > Bachelor 1 10%
Professor 1 10%
Other 0 0%
Unknown 1 10%
Readers by discipline Count As %
Chemistry 2 20%
Medicine and Dentistry 2 20%
Immunology and Microbiology 1 10%
Agricultural and Biological Sciences 1 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 10%
Other 1 10%
Unknown 2 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2021.
All research outputs
#2,784,693
of 19,878,206 outputs
Outputs from International Journal of Nanomedicine
#157
of 3,438 outputs
Outputs of similar age
#79,521
of 434,245 outputs
Outputs of similar age from International Journal of Nanomedicine
#7
of 113 outputs
Altmetric has tracked 19,878,206 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,438 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 434,245 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.