| Title |
Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance
|
|---|---|
| Published in |
Integrated Blood Pressure Control, December 2014
|
| DOI | 10.2147/ibpc.s51434 |
| Pubmed ID | |
| Authors |
Karin Ried, Peter Fakler |
| Abstract |
Garlic supplements have shown promise in the treatment of uncontrolled hypertension, lowering blood pressure (BP) by about 10 mmHg systolic and 8 mmHg diastolic, similar to standard BP medication. Aged garlic extract, which contains S-allylcysteine as the bioactive sulfur compound, in particular is standardizable and highly tolerable, with little or no known harmful interaction when taken with other BP-reducing or blood-thinning medication. Here we describe biologically plausible mechanisms of garlic's BP-lowering effect. Garlic-derived polysulfides stimulate the production of the vascular gasotransmitter hydrogen sulfide (H2S) and enhance the regulation of endothelial nitric oxide (NO), which induce smooth muscle cell relaxation, vasodilation, and BP reduction. Several dietary and genetic factors influence the efficiency of the H2S and NO signaling pathways and may contribute to the development of hypertension. Sulfur deficiency might play a part in the etiology of hypertension, and could be alleviated with supplementation of organosulfur compounds derived from garlic. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 33% |
| Saudi Arabia | 1 | 5% |
| Latvia | 1 | 5% |
| Netherlands | 1 | 5% |
| Canada | 1 | 5% |
| Unknown | 10 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 67% |
| Scientists | 4 | 19% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 406 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Honduras | 1 | <1% |
| Egypt | 1 | <1% |
| Unknown | 401 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 105 | 26% |
| Student > Master | 51 | 13% |
| Student > Ph. D. Student | 24 | 6% |
| Student > Doctoral Student | 19 | 5% |
| Lecturer | 13 | 3% |
| Other | 53 | 13% |
| Unknown | 141 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 73 | 18% |
| Nursing and Health Professions | 36 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 34 | 8% |
| Biochemistry, Genetics and Molecular Biology | 33 | 8% |
| Agricultural and Biological Sciences | 30 | 7% |
| Other | 57 | 14% |
| Unknown | 143 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 282. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2023.
All research outputs
#127,290
of 25,657,205 outputs
Outputs from Integrated Blood Pressure Control
#1
of 78 outputs
Outputs of similar age
#1,271
of 370,619 outputs
Outputs of similar age from Integrated Blood Pressure Control
#1
of 1 outputs
Altmetric has tracked 25,657,205 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.3. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 370,619 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
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