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| Title |
Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, December 2017
|
| DOI | 10.2147/ndt.s150488 |
| Pubmed ID | |
| Authors |
Fidel Vila-Rodriguez, Donna J Lang, Heather Baitz, Kristina Gicas, Allen E Thorton, Thomas S Ehmann, Geoff N Smith, Alasdair M Barr, Ivan J Torres, Lili C Kopala, G William MacEwan, Daniel J Müller, James L Kennedy, William G Honer |
| Abstract |
Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimer's disease. Our primary goal was to ascertain whether APOE-ε4 status had a pleiotropic effect in early stages of the illness. A total of 86 first-episode psychosis (FEP) outpatients and 39 healthy volunteers were recruited. Demographic and clinical data, APOE genotyping, and a neuropsychological test battery including the California Verbal Learning Test - second edition (CVLT-II) were administered and assessed at study entry and at 1-year follow-up. Data were analyzed using mixed-model repeated measures, where the dependent variable was verbal memory indexed by California Verbal Learning Test (CVLT) Trials 1-5 total recall score. FEP-APOE-ε4 carriers and FEP-APOE-ε4 noncarriers had similar symptom severity, clinical outcomes, premorbid and current intelligence quotient, and exposure to antipsychotics. There was a main effect of group on CVLT 1-5 (FEP =43.30 vs control =58.25; F[1, 119.7]=42.97; P<0.001) as well as an APOE-ε4 by group by time (F[4, 116.2]=2.73, P=0.033) interaction with only FEP-APOE-ε4 carriers showing improved verbal memory at follow-up. Our study is the first to report improvement in verbal memory in persons afflicted by FEP who are APOE-ε4 carriers and replicates the prominent verbal memory deficits present in FEP. Our work provides further evidence pointing to an antagonistic pleiotropic effect of APOE-ε4 in neuropsychiatric disorders. Our results merit further research into antagonistic pleiotropic effects in schizophrenia. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | 50% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 67% |
| Practitioners (doctors, other healthcare professionals) | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 32% |
| Student > Doctoral Student | 4 | 11% |
| Lecturer | 3 | 8% |
| Student > Bachelor | 2 | 5% |
| Professor > Associate Professor | 2 | 5% |
| Other | 5 | 14% |
| Unknown | 9 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 6 | 16% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Medicine and Dentistry | 3 | 8% |
| Neuroscience | 2 | 5% |
| Nursing and Health Professions | 1 | 3% |
| Other | 7 | 19% |
| Unknown | 15 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2019.
All research outputs
#7,852,306
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,024
of 3,131 outputs
Outputs of similar age
#142,807
of 444,941 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#26
of 67 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,131 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 444,941 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.