| Title |
Rational use of the fixed combination of dorzolamide – timolol in the management of raised intraocular pressure and glaucoma
|
|---|---|
| Published in |
Clinical Ophthalmology, June 2008
|
| DOI | 10.2147/opth.s1813 |
| Pubmed ID | |
| Authors |
Jason Yeh, Daniel Kravitz, Brian Francis |
| Abstract |
Glaucoma is a multifactorial optic neuropathy in which the main therapeutic target is lowering of intraocular pressure (IOP) in order to retard the progression of existing structural and functional damage. The three mainstays of treatment are pharmacologic, laser, and surgical. The primary standard therapy in patients with open-angle glaucoma or ocular hypertension is topical medication. When monotherapy does not adequately lower the intraocular pressure, one or more agents are added or substituted. Combination pharmacotherapy such as Cosopt((R)) is available to improve efficacy and simplify medication regimen. A fixed combination of two ocular hypotensive drugs (the carbonic anhydrase inhibitor dorzolamide and the beta-adrenoceptor antagonist timolol), Cosopt((R)) is indicated for the treatment of elevated IOP in patients with open-angle glaucoma or ocular hypertension insufficiently responsive to topical beta-adrenoceptor antagonist monotherapy. Compared with concomitant therapy with the individual components, the primary advantage of fixed combination dorzolamide - timolol is convenience, which may also improve compliance. Clinical trials have demonstrated that the fixed combination dorzolamide - timolol is safe, effective and generally well tolerated in lowering IOP in patients with open angle glaucoma or ocular hypertension, including individuals uncontrolled on beta-adrenoceptor antagonist or other monotherapy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 21% |
| Other | 1 | 7% |
| Student > Doctoral Student | 1 | 7% |
| Unspecified | 1 | 7% |
| Student > Bachelor | 1 | 7% |
| Other | 3 | 21% |
| Unknown | 4 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 14% |
| Medicine and Dentistry | 2 | 14% |
| Unspecified | 1 | 7% |
| Chemical Engineering | 1 | 7% |
| Agricultural and Biological Sciences | 1 | 7% |
| Other | 3 | 21% |
| Unknown | 4 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2015.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from Clinical Ophthalmology
#1,803
of 3,712 outputs
Outputs of similar age
#83,698
of 97,665 outputs
Outputs of similar age from Clinical Ophthalmology
#14
of 14 outputs
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