Title |
Spotlight on solithromycin in the treatment of community-acquired bacterial pneumonia: design, development, and potential place in therapy
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Published in |
Drug Design, Development and Therapy, December 2017
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DOI | 10.2147/dddt.s119545 |
Pubmed ID | |
Authors |
Bryan J Donald, Salim Surani, Harmeet S Deol, Uche J Mbadugha, George Udeani |
Abstract |
Community-acquired bacterial pneumonia (CABP) is a leading cause of death worldwide. However, antibacterial agents used to treat common pathogens in CABP are marked by adverse drug events and increasing antimicrobial resistance. Solithromycin is a new ketolide antibiotic, based on the macrolide antibiotic structure, being studied for use in CABP. It has efficacy in vitro against the common causative pathogens in CABP including Streptococcus pneumoniae, Haemophilus influenzae, and atypical pathogens. In Phase II and Phase III clinical trials, it has been demonstrated efficacious as a single agent for treatment of CABP with an apparently milder adverse event profile than alternative agents. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 16% |
Researcher | 4 | 11% |
Student > Ph. D. Student | 4 | 11% |
Student > Postgraduate | 3 | 8% |
Student > Master | 3 | 8% |
Other | 4 | 11% |
Unknown | 14 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
Biochemistry, Genetics and Molecular Biology | 3 | 8% |
Chemistry | 3 | 8% |
Neuroscience | 2 | 5% |
Other | 5 | 13% |
Unknown | 14 | 37% |