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Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity

Overview of attention for article published in International Journal of Nanomedicine, December 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent
facebook
1 Facebook page

Citations

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37 Dimensions

Readers on

mendeley
46 Mendeley
Title
Hemagglutinin-based polyanhydride nanovaccines against H5N1 influenza elicit protective virus neutralizing titers and cell-mediated immunity
Published in
International Journal of Nanomedicine, December 2014
DOI 10.2147/ijn.s72264
Pubmed ID
Authors

Balaji Narasimhan, Kathleen Ross, Hylee Loyd, Wuwei Wu, Lucas Huntimer, Shaheen Ahmed, Anthony Sambol, Scott Broderick, Zachary Flickinger, Krishna Rajan, Surya Mallapragada, Michael Wannemuehler, Susan Carpenter, Tatiana Bronich

Abstract

H5N1 avian influenza is a significant global concern with the potential to become the next pandemic threat. Recombinant subunit vaccines are an attractive alternative for pandemic vaccines compared to traditional vaccine technologies. In particular, polyanhydride nanoparticles encapsulating subunit proteins have been shown to enhance humoral and cell-mediated immunity and provide protection upon lethal challenge. In this work, a recombinant H5 hemagglutinin trimer (H53) was produced and encapsulated into polyanhydride nanoparticles. The studies performed indicated that the recombinant H53 antigen was a robust immunogen. Immunizing mice with H53 encapsulated into polyanhydride nanoparticles induced high neutralizing antibody titers and enhanced CD4(+) T cell recall responses in mice. Finally, the H53-based polyanhydride nanovaccine induced protective immunity against a low-pathogenic H5N1 viral challenge. Informatics analyses indicated that mice receiving the nanovaccine formulations and subsequently challenged with virus were similar to naïve mice that were not challenged. The current studies provide a basis to further exploit the advantages of polyanhydride nanovaccines in pandemic scenarios.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 46 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 26%
Student > Bachelor 7 15%
Student > Doctoral Student 6 13%
Researcher 4 9%
Student > Master 4 9%
Other 9 20%
Unknown 4 9%
Readers by discipline Count As %
Chemical Engineering 9 20%
Agricultural and Biological Sciences 7 15%
Engineering 5 11%
Immunology and Microbiology 5 11%
Biochemistry, Genetics and Molecular Biology 4 9%
Other 10 22%
Unknown 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2020.
All research outputs
#6,003,217
of 19,846,165 outputs
Outputs from International Journal of Nanomedicine
#653
of 3,434 outputs
Outputs of similar age
#92,259
of 332,363 outputs
Outputs of similar age from International Journal of Nanomedicine
#7
of 47 outputs
Altmetric has tracked 19,846,165 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 3,434 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,363 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.