Title |
Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones
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Published in |
Drug Design, Development and Therapy, November 2017
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DOI | 10.2147/dddt.s149615 |
Pubmed ID | |
Authors |
Galal Elgemeie, Farag Altalbawy, Mohammed Alfaidi, Rania Azab, Atef Hassan |
Abstract |
The present research describes the synthesis of novel 5-benzoyl-N-substituted-amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones 5a-c and 6a-c via the reaction of 2-benzoyl-3,3-bis(alkylthio)acrylonitriles 2a-c with N-cyanoacetohydrazide 3 and cyanoaceto-N-phenylsulfonylhydrazide 4, respectively. Also, the reactivity of the compounds 5a-c toward hydrazine hydrate to give product 1H-pyrazolo[4,3-c]pyridine derivative 7 was studied. In addition, the reactivity of the 2a-c toward 1-cyanoacetyl-4 arylidenesemicarbazides 8a-c afforded 3,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile derivatives (12-14)a-c, which reacted with hydrazine hydrate to give 3H-pyrazolo[4,3-c][1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile derivatives 15a-c. The structures of the new products were characterized based on 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, infrared, mass-spectroscopy, and elemental analyses. The products were screened in vitro for their antibacterial and antifungal activity properties. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 13 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 15% |
Other | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Lecturer | 1 | 8% |
Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 6 | 46% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 15% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Immunology and Microbiology | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Engineering | 1 | 8% |
Other | 0 | 0% |
Unknown | 7 | 54% |