| Title |
Association between coffee or caffeine consumption and fecundity and fertility: a systematic review and dose–response meta-analysis
|
|---|---|
| Published in |
Clinical Epidemiology, December 2017
|
| DOI | 10.2147/clep.s146496 |
| Pubmed ID | |
| Authors |
Julie Lyngsø, Cecilia Høst Ramlau-Hansen, Bjørn Bay, Hans Jakob Ingerslev, Adam Hulman, Ulrik Schiøler Kesmodel |
| Abstract |
The aim was to investigate whether coffee or caffeine consumption is associated with reproductive endpoints among women with natural fertility (ie, time to pregnancy [TTP] and spontaneous abortion [SAB]) and among women in fertility treatment (ie, clinical pregnancy rate or live birth rate). This study was a systematic review and dose-response meta-analysis including data from case-control and cohort studies. An extensive literature search was conducted in MEDLINE and Embase, with no time and language restrictions. Also, reference lists were searched manually. Two independent reviewers assessed the manuscript quality using the Newcastle-Ottawa Scale (NOS). A two-stage dose-response meta-analysis was applied to assess a potential association between coffee/caffeine consumption and the outcomes: TTP, SAB, clinical pregnancy, and live birth. Heterogeneity between studies was assessed using Cochrane Q-test and I2 statistics. Publication bias was assessed using Egger's regression test. The pooled results showed that coffee/caffeine consumption is associated with a significantly increased risk of SAB for 300 mg caffeine/day (relative risk [RR]: 1.37, 95% confidence interval [95% CI]: 1.19; 1.57) and for 600 mg caffeine/day (RR: 2.32, 95% CI: 1.62; 3.31). No association was found between coffee/caffeine consumption and outcomes of fertility treatment (based on two studies). No clear association was found between exposure to coffee/caffeine and natural fertility as measured by fecundability odds ratio (based on three studies) or waiting TTP (based on two studies). Results from this meta-analysis support the growing evidence of an association between coffee/caffeine intake and the risk of SAB. However, viewing the reproductive capacity in a broader perspective, there seems to be little, if any, association between coffee/caffeine consumption and fecundity. In general, results from this study are supportive of a precautionary principle advised by health organizations such as European Food Safety Authority (EFSA) and World Health Organization (WHO), although the advised limit of a maximum of two to three cups of coffee/200-300 mg caffeine per day may be too high. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 140 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 29 | 21% |
| Researcher | 16 | 11% |
| Student > Master | 16 | 11% |
| Student > Ph. D. Student | 9 | 6% |
| Other | 8 | 6% |
| Other | 15 | 11% |
| Unknown | 47 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 24% |
| Nursing and Health Professions | 18 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 5% |
| Agricultural and Biological Sciences | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 17 | 12% |
| Unknown | 52 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2024.
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#368,410
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Outputs from Clinical Epidemiology
#17
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Outputs of similar age from Clinical Epidemiology
#2
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