| Title |
Treatment of bipolar disorders during pregnancy: maternal and fetal safety and challenges
|
|---|---|
| Published in |
Drug, Healthcare and Patient Safety, December 2014
|
| DOI | 10.2147/dhps.s50556 |
| Pubmed ID | |
| Authors |
Richard A Epstein, Katherine M Moore, William V Bobo |
| Abstract |
Treating pregnant women with bipolar disorder is among the most challenging clinical endeavors. Patients and clinicians are faced with difficult choices at every turn, and no approach is without risk. Stopping effective pharmacotherapy during pregnancy exposes the patient and her baby to potential harms related to bipolar relapses and residual mood symptom-related dysfunction. Continuing effective pharmacotherapy during pregnancy may prevent these occurrences for many; however, some of the most effective pharmacotherapies (such as valproate) have been associated with the occurrence of congenital malformations or other adverse neonatal effects in offspring. Very little is known about the reproductive safety profile and clinical effectiveness of atypical antipsychotic drugs when used to treat bipolar disorder during pregnancy. In this paper, we provide a clinically focused review of the available information on potential maternal and fetal risks of untreated or undertreated maternal bipolar disorder during pregnancy, the effectiveness of interventions for bipolar disorder management during pregnancy, and potential obstetric, fetal, and neonatal risks associated with core foundational pharmacotherapies for bipolar disorder. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 33% |
| United States | 1 | 11% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Practitioners (doctors, other healthcare professionals) | 3 | 33% |
| Scientists | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 154 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 154 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 13% |
| Researcher | 17 | 11% |
| Other | 16 | 10% |
| Student > Master | 16 | 10% |
| Student > Postgraduate | 12 | 8% |
| Other | 23 | 15% |
| Unknown | 50 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 48 | 31% |
| Nursing and Health Professions | 13 | 8% |
| Psychology | 10 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Neuroscience | 7 | 5% |
| Other | 16 | 10% |
| Unknown | 52 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 75. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2023.
All research outputs
#580,389
of 25,711,518 outputs
Outputs from Drug, Healthcare and Patient Safety
#4
of 161 outputs
Outputs of similar age
#6,844
of 371,058 outputs
Outputs of similar age from Drug, Healthcare and Patient Safety
#1
of 4 outputs
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So far Altmetric has tracked 161 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done particularly well, scoring higher than 97% of its peers.
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