Title |
Targeting IL-23 in psoriasis: current perspectives
|
---|---|
Published in |
Psoriasis : Targets and Therapy, January 2018
|
DOI | 10.2147/ptt.s98893 |
Pubmed ID | |
Authors |
Christina Fotiadou, Elizabeth Lazaridou, Eleni Sotiriou, Demetrios Ioannides |
Abstract |
The recent advances in the understanding of psoriasis pathogenesis have clarified the pivotal role of interleukin (IL)-23. It is a heterodimeric cytokine consisting of two subunits, the unique p19 and the p40, which are shared with IL-12. The basic role of IL-23 in psoriasis is the activation and maintenance of the T-helper 17 pathway. New research findings indicate that IL-23 is more important than IL-12 in the pathogenesis of psoriasis. Based on that background, the selective targeting of the IL-23p19 subunit emerged as an attractive therapeutic option and led to the development of a new category of biologic agents. Three monoclonal antibodies that selectively inhibit the IL-23p19 subunit, guselkumab, tildrakizumab, and risankizumab, are in the pipeline for the treatment of moderate-to-severe psoriasis. In this article, we review the most recent efficacy and safety data regarding these IL-23p19 inhibitors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 103 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 14% |
Researcher | 12 | 12% |
Other | 10 | 10% |
Student > Ph. D. Student | 9 | 9% |
Student > Doctoral Student | 8 | 8% |
Other | 12 | 12% |
Unknown | 38 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 14 | 14% |
Immunology and Microbiology | 9 | 9% |
Biochemistry, Genetics and Molecular Biology | 6 | 6% |
Agricultural and Biological Sciences | 2 | 2% |
Other | 6 | 6% |
Unknown | 38 | 37% |