Title |
Diagnostic challenges in multiple system atrophy
|
---|---|
Published in |
Neuropsychiatric Disease and Treatment, January 2018
|
DOI | 10.2147/ndt.s146080 |
Pubmed ID | |
Authors |
Diana Obelieniene, Sandra Bauzaite, Ilona Kulakiene, Evaldas Keleras, Indre Eitmonaite, Daiva Rastenyte |
Abstract |
Multiple system atrophy is a progressive neurodegenerative disorder that is characterized by autonomic failure, cerebellar ataxia and parkinsonism syndrome in various combinations. In spite of the presence of well-established clinical criteria for multiple system atrophy, ante-mortem diagnosis is difficult. In our case report, we present a 78-year-old female patient who presented with early progressive aphasia and severe autonomic dysfunction. Two years after appearance of the first symptoms, she fulfilled all the major criteria for probable multiple system atrophy with rapid progression. In addition, brain magnetic resonance imaging and fluorodeoxyglucose-positron emission tomography findings were more typical for progressive supranuclear palsy. Clinically differentiating multiple system atrophy from progressive supranuclear palsy and other similar neurodegenerative disorders may be challenging in all stages of the disease, especially with atypical disease presentation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 20% |
United States | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 7 | 21% |
Student > Bachelor | 5 | 15% |
Student > Doctoral Student | 4 | 12% |
Student > Ph. D. Student | 3 | 9% |
Researcher | 2 | 6% |
Other | 7 | 21% |
Unknown | 5 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 30% |
Nursing and Health Professions | 8 | 24% |
Psychology | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Business, Management and Accounting | 1 | 3% |
Other | 2 | 6% |
Unknown | 9 | 27% |