| Title |
The association between hippocampal subfield volumes and education in cognitively normal older adults and amnestic mild cognitive impairment patients
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, January 2018
|
| DOI | 10.2147/ndt.s151659 |
| Pubmed ID | |
| Authors |
Dong Woo Kang, Hyun Kook Lim, Soo-hyun Joo, Na Rae Lee, Chang Uk Lee |
| Abstract |
Previous research has indicated that there are potential associations between education and total hippocampal volume in the trajectory of Alzheimer's disease (AD). However, the correlation between education and hippocampal subfield volumes in the progression of AD has yet to be understood. This study examined the relationship between education, which is a standard proxy for cognitive reserve, and hippocampal subfield volumes in healthy and amnestic mild cognitive impairment (aMCI) groups. Thirty-eight subjects with aMCI and 39 healthy control subjects underwent 3 T magnetic resonance imaging, and hippocampal subfield volumes were measured by automated segmentation. Multiple linear regression analysis was used to determine the association between education and hippocampal subfield volumes. Education had a significant negative correlation with the left parasubiculum, presubiculum, and subiculum volumes in the aMCI group. In addition, multiple subfield volumes including left parasubiculum, left/right presubiculum, left cornus ammonis (CA)3, and left CA4 showed a significant correlation with the neuropsychological test scores in the control group and aMCI group. These findings contribute to a better understanding of the association between education, hippocampal subfield volumes, and amnestic cognitive functions in the early phase of AD. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 23% |
| Researcher | 9 | 19% |
| Student > Bachelor | 6 | 13% |
| Student > Master | 4 | 9% |
| Student > Doctoral Student | 2 | 4% |
| Other | 7 | 15% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 21% |
| Psychology | 9 | 19% |
| Medicine and Dentistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Computer Science | 1 | 2% |
| Other | 5 | 11% |
| Unknown | 16 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2018.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#2,583
of 3,131 outputs
Outputs of similar age
#389,382
of 449,550 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#61
of 76 outputs
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