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Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population

Overview of attention for article published in Therapeutics and Clinical Risk Management, January 2018
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1 tweeter

Citations

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3 Dimensions

Readers on

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11 Mendeley
Title
Raised serum uric acid is associated with higher bone mineral density in a cross-sectional study of a healthy Indian population
Published in
Therapeutics and Clinical Risk Management, January 2018
DOI 10.2147/tcrm.s147696
Pubmed ID
Authors

Neelam Kaushal, Divya Vohora, Rajinder Jalali, Sujeet Jha

Abstract

Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Reactive oxygen species are reported to suppress osteoblast generation and differentiation and enhance osteoclast development and activity. Increasing evidence suggests favorable effect of serum uric acid (UA) on bone metabolism due to its antioxidant properties. Therefore, we investigated the association between serum UA levels and bone mineral density (BMD) in healthy adult Indian subjects. We reviewed the medical records of 524 subjects who had undergone preventive health check-ups in a tertiary care hospital that included UA and BMD measurements at femur neck, total femur, and lumbar spine. Subjects concomitantly taking drugs or having a medical condition that would affect the bone metabolism or UA levels were excluded. The final analysis included 310 subjects (mean age: 47.2±12.2 years; females: 43.5%; males: 56.5%). Study population was categorized into two groups based on the group median value for UA (ie, 5.4 mg/dL). BMD was significantly higher at all skeletal sites in subjects with UA >5.4 mg/dL compared to subjects with UA ≤5.4 mg/dL (p<0.001). On correlation analysis, UA was positively associated with BMD at all skeletal sites (r=0.211-0.277; p<0.05). The correlation remained significant after controlling for age (p<0.05) and lifestyle factors (smoking, alcohol use, physical activity, and diet; p<0.05) independently. UA significantly (p<0.001) accounted for 4.5%-7.7% of the variance in BMD (r2=0.045-0.077) in unadjusted model and 1.6%-3.2% of the variance (p<0.05) when adjusted for age and body mass index combined at lumbar spine and right femur neck, respectively. We conclude that raised UA levels are associated with higher BMD at all skeletal sites and UA may have a protective role in bone metabolism owing to its antioxidant effect.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 2 18%
Student > Master 1 9%
Student > Bachelor 1 9%
Researcher 1 9%
Student > Doctoral Student 1 9%
Other 0 0%
Unknown 5 45%
Readers by discipline Count As %
Medicine and Dentistry 2 18%
Neuroscience 1 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 9%
Unknown 7 64%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2018.
All research outputs
#7,834,181
of 12,485,238 outputs
Outputs from Therapeutics and Clinical Risk Management
#644
of 922 outputs
Outputs of similar age
#210,897
of 375,545 outputs
Outputs of similar age from Therapeutics and Clinical Risk Management
#18
of 34 outputs
Altmetric has tracked 12,485,238 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 922 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 375,545 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.