| Title |
Functional impairment in patients with major depressive disorder: the 2-year PERFORM study
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, January 2018
|
| DOI | 10.2147/ndt.s146098 |
| Pubmed ID | |
| Authors |
Lene Hammer-Helmich, Josep Maria Haro, Bengt Jönsson, Audrey Tanguy Melac, Sylvie Di Nicola, Julien Chollet, Dominique Milea, Benoît Rive, Delphine Saragoussi |
| Abstract |
The Prospective Epidemiological Research on Functioning Outcomes Related to Major depressive disorder (PERFORM) study describes the course of depressive symptoms, perceived cognitive symptoms, and functional impairment over 2 years in outpatients with major depressive disorder (MDD) and investigates the patient-related factors associated with functional impairment. This was a 2-year observational study in 1,159 outpatients with MDD aged 18-65 years who were either initiating antidepressant monotherapy or undergoing their first switch of antidepressant. Functional impairment was assessed by the Sheehan Disability Scale and the Work Productivity and Activity Impairment questionnaire. Patients assessed depression severity using the nine-item Patient Health Questionnaire and severity of perceived cognitive symptoms using the five-item Perceived Deficit Questionnaire. To investigate which patient-related factors were associated with functional impairment, univariate analyses of variance were performed to identify relevant factors that were then included in multivariate analyses of covariance at baseline, month 2, months 6 and 12 combined, and months 18 and 24 combined. The greatest improvement in depressive symptoms, perceived cognitive symptoms, and functional impairment was seen immediately (within 2 months) following initiation or switch of antidepressant therapy, followed by more gradual improvement and long-term stabilization. Improvement in perceived cognitive symptoms was less marked than improvement in depressive symptoms during the acute treatment phase. Functional impairment in patients with MDD was not only associated with severity of depressive symptoms but also independently associated with severity of perceived cognitive symptoms when adjusted for depression severity throughout the 2 years of follow-up. These findings highlight the burden of functional impairment in MDD and the importance of recognizing and managing cognitive symptoms in daily practice. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 158 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 158 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 16% |
| Student > Ph. D. Student | 19 | 12% |
| Student > Master | 19 | 12% |
| Student > Bachelor | 10 | 6% |
| Other | 8 | 5% |
| Other | 26 | 16% |
| Unknown | 51 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 17% |
| Psychology | 23 | 15% |
| Nursing and Health Professions | 12 | 8% |
| Neuroscience | 7 | 4% |
| Unspecified | 5 | 3% |
| Other | 28 | 18% |
| Unknown | 56 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2019.
All research outputs
#7,208,166
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#914
of 3,131 outputs
Outputs of similar age
#134,680
of 449,550 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#21
of 76 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 3,131 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
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We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.