Title |
Controlled drug delivery for glaucoma therapy using montmorillonite/Eudragit microspheres as an ion-exchange carrier
|
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Published in |
International Journal of Nanomedicine, January 2018
|
DOI | 10.2147/ijn.s146346 |
Pubmed ID | |
Authors |
Shuangyan Tian, Juan Li, Qi Tao, Yawen Zhao, Zhufen Lv, Fan Yang, Haoyun Duan, Yanzhong Chen, Qingjun Zhou, Dongzhi Hou |
Abstract |
Glaucoma is a serious eye disease that can lead to loss of vision. Unfortunately, effective treatments are limited by poor bioavailability of antiglaucoma medicine due to short residence time on the preocular surface. To solve this, we successfully prepared novel controlled-release ion-exchange microparticles to deliver betaxolol hydrochloride (BH). Montmorillonite/BH complex (Mt-BH) was prepared by acidification-intercalation, and this complex was encapsulated in microspheres (Mt-BH encapsulated microspheres [BMEMs]) by oil-in-oil emulsion-solvent evaporation method. The BH loaded into ion-exchange Mt was 47.45%±0.54%. After the encapsulation of Mt-BH into Eudragit microspheres, the encapsulation efficiency of BH into Eudragit microspheres was 94.35%±1.01% and BH loaded into Eudragit microspheres was 14.31%±0.47%. Both Fourier transform infrared spectra and X-ray diffraction patterns indicated that BH was successfully intercalated into acid-Mt to form Mt-BH and then Mt-BH was encapsulated into Eudragit microspheres to obtain BMEMs. Interestingly, in vitro release duration of the prepared BMEMs was extended to 12 hours, which is longer than both of the BH solution (2.5 hours) and the conventional BH microspheres (5 hours). Moreover, BMEM exhibited lower toxicity than that of BH solution as shown by the results of cytotoxicity tests, chorioallantoic membrane-trypan blue staining, and Draize rabbit eye test. In addition, both in vivo and in vitro preocular retention capacity study of BMEMs showed a prolonged retention time. The pharmacodynamics showed that BMEMs could extend the drug duration of action. The developed BMEMs have the potential to be further applied as ocular drug delivery systems for the treatment of glaucoma. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 39 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 23% |
Researcher | 4 | 10% |
Professor | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Other | 6 | 15% |
Unknown | 12 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 9 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Chemistry | 4 | 10% |
Medicine and Dentistry | 2 | 5% |
Computer Science | 1 | 3% |
Other | 3 | 8% |
Unknown | 16 | 41% |