| Title |
Relationship of vitamin D receptor gene polymorphisms in Helicobacter pylori gastric patients
|
|---|---|
| Published in |
Clinical and Experimental Gastroenterology, January 2018
|
| DOI | 10.2147/ceg.s143332 |
| Pubmed ID | |
| Authors |
Dinelma de Jesus Martins, Gyselly CB Matos, Rosane SP Loiola, Vivian D’Annibale, Tereza Corvelo |
| Abstract |
The present study aimed to investigate the association between the human VDR gene and Helicobacter pylori infection. A cross-sectional study was conducted on 208 adult patients with upper gastrointestinal symptoms. Gastric biopsy specimens were obtained from each patient for molecular DNA and histological examination. Patients were genotyped for VDR gene polymorphisms using polymerase chain reaction and restriction fragment length polymorphism analysis. The allelic and genotypic distribution analyses of the FokI, ApaI and TaqI polymorphisms of the VDR gene did not show distribution differences between H. pylori-positive and -negative groups. The genotype distribution observed for polymorphism BsmI deviated significantly from what was expected in a Hardy-Weinberg equilibrium test in the H. pylori-positive group (χ2=29.048, p<0.001). The distribution of BsmI genotypes differed significantly between the H. pylori-negative and H. pylori-positive groups (p=0.0034), where the frequency of the bb genotype increased among H. pylori-positive individuals compared with those without infection (63.25% versus 50.55%, respectively). Conversely, the H. pylori-negative group showed a Bb frequency that was 20.27% higher than in the infected group. We identified a possible association between the BsmI polymorphism and infection by H. pylori. However, further research is required to clarify this relationship. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 6 | 30% |
| Student > Bachelor | 3 | 15% |
| Student > Ph. D. Student | 2 | 10% |
| Researcher | 2 | 10% |
| Student > Doctoral Student | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 5 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 4 | 20% |
| Biochemistry, Genetics and Molecular Biology | 3 | 15% |
| Nursing and Health Professions | 2 | 10% |
| Agricultural and Biological Sciences | 2 | 10% |
| Immunology and Microbiology | 2 | 10% |
| Other | 1 | 5% |
| Unknown | 6 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2018.
All research outputs
#14,519,165
of 25,584,565 outputs
Outputs from Clinical and Experimental Gastroenterology
#152
of 311 outputs
Outputs of similar age
#218,973
of 450,901 outputs
Outputs of similar age from Clinical and Experimental Gastroenterology
#5
of 8 outputs
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So far Altmetric has tracked 311 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one has gotten more attention than average, scoring higher than 50% of its peers.
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We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.