Title |
Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease
|
---|---|
Published in |
International Journal of Chronic Obstructive Pulmonary Disease, January 2018
|
DOI | 10.2147/copd.s152291 |
Pubmed ID | |
Authors |
Donald P Tashkin, Michael E Wechsler |
Abstract |
COPD is a significant cause of morbidity and mortality. In some patients with COPD, eosinophils contribute to inflammation that promotes airway obstruction; approximately a third of stable COPD patients have evidence of eosinophilic inflammation. Although the eosinophil threshold associated with clinical relevance in patients with COPD is currently subject to debate, eosinophil counts hold potential as biomarkers to guide therapy. In particular, eosinophil counts may be useful in assessing which patients may benefit from inhaled corticosteroid therapy, particularly regarding exacerbation prevention. In addition, several therapies targeting eosinophilic inflammation are available or in development, including monoclonal antibodies targeting the IL5 ligand, the IL5 receptor, IL4, and IL13. The goal of this review was to describe the biologic characteristics of eosinophils, their role in COPD during exacerbations and stable disease, and their use as biomarkers to aid treatment decisions. We also propose an algorithm for inhaled corticosteroid use, taking into consideration eosinophil counts and pneumonia history, and emerging eosinophil-targeted therapies in COPD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 38% |
France | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 63% |
Practitioners (doctors, other healthcare professionals) | 1 | 13% |
Scientists | 1 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 224 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 33 | 15% |
Other | 24 | 11% |
Student > Master | 21 | 9% |
Student > Ph. D. Student | 19 | 8% |
Student > Postgraduate | 17 | 8% |
Other | 43 | 19% |
Unknown | 67 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 78 | 35% |
Pharmacology, Toxicology and Pharmaceutical Science | 23 | 10% |
Biochemistry, Genetics and Molecular Biology | 18 | 8% |
Agricultural and Biological Sciences | 10 | 4% |
Immunology and Microbiology | 6 | 3% |
Other | 13 | 6% |
Unknown | 76 | 34% |