Title |
Activity of siderophores against drug-resistant Gram-positive and Gram-negative bacteria
|
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Published in |
Infection and Drug Resistance, January 2018
|
DOI | 10.2147/idr.s148602 |
Pubmed ID | |
Authors |
Karuna Gokarn, Ramprasad B Pal |
Abstract |
Infections by drug-resistant bacteria are life-threatening. As iron is a vital element for the growth of bacteria, iron-chelating agents (siderophores) can be used to arrest their multiplication. Exogenous siderophores - exochelin-MS and deferoxamine-B - were evaluated for their inhibitory activity against methicillin-resistant Staphylococcus aureus and metallo-β-lactamase producers - Pseudomonas aeruginosa and Acinetobacter baumannii - by disc diffusion, micro-broth dilution, and turbidimetric growth assays. The drug-resistant isolates were inhibited by the synergistic activity of siderophores and antibiotics. Minimum inhibitory concentration of exochelin-MS+ampicillin for different isolates was between 0.05 and 0.5 mg/mL. Minimum inhibitory concentration of deferoxamine-B+ampicillin was 1.0 mg/mL and greater. Iron-chelation therapy could provide a complementary approach to overcome drug resistance in pathogenic bacteria. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 17% |
Unspecified | 5 | 12% |
Student > Postgraduate | 4 | 10% |
Student > Ph. D. Student | 4 | 10% |
Researcher | 3 | 7% |
Other | 6 | 15% |
Unknown | 12 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 8 | 20% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Unspecified | 4 | 10% |
Agricultural and Biological Sciences | 3 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 6 | 15% |
Unknown | 14 | 34% |