| Title |
Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease
|
|---|---|
| Published in |
International Journal of Chronic Obstructive Pulmonary Disease, February 2018
|
| DOI | 10.2147/copd.s146870 |
| Pubmed ID | |
| Authors |
Xianwei Hu, Haibao Wang, Youhui Tu, Mengdi Fei, Minmin Yin, Guanghe Fei, Yongqiang Yu |
| Abstract |
Cognitive impairment is a common extrapulmonary comorbidity in COPD patients. The default mode network (DMN) plays a critical role in maintaining the normal activities of humans, and its function can be evaluated by resting state functional magnetic resonance imaging. The aim of this study was to investigate the correlations between cognition and function changes of the DMN in COPD patients. One hundred and thirteen eligible participants including 30 control subjects and 83 COPD patients matched for demographic characteristics were recruited. All participants performed cognitive function tests and underwent resting state functional magnetic resonance imaging. The total cognitive function scores of COPD patients were significantly different from those of control subjects (P<0.05) and worsened with the degree of airflow obstruction. The activated brain regions in the DMN of COPD patients were less than those of normal controls. Six activated brain regions in the DMN were found to develop significantly different functional connectivity (FC) values among the subjects. Meanwhile, the FC values of the left posterior cingulate cortex and left hippocampus correlated well with cognitive functions and pulmonary function. COPD patients have cognitive impairments that correlate well with disease severity. FC changes in activated brain regions in the DMN may predict cognitive impairment, and the left posterior cingulate cortex and left hippocampus may be important brain regions related to cognitive impairment in COPD patients. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Canada | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 30% |
| Student > Postgraduate | 3 | 11% |
| Other | 2 | 7% |
| Student > Master | 2 | 7% |
| Lecturer | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 7 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 22% |
| Medicine and Dentistry | 5 | 19% |
| Nursing and Health Professions | 2 | 7% |
| Psychology | 2 | 7% |
| Philosophy | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 9 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2018.
All research outputs
#14,519,165
of 25,584,565 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,178
of 2,571 outputs
Outputs of similar age
#218,858
of 450,135 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#39
of 71 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,571 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,135 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.