| Title |
The effect of exercise frequency on neuropathic pain and pain-related cellular reactions in the spinal cord and midbrain in a rat sciatic nerve injury model
|
|---|---|
| Published in |
Journal of Pain Research, February 2018
|
| DOI | 10.2147/jpr.s156326 |
| Pubmed ID | |
| Authors |
Megumi Sumizono, Harutoshi Sakakima, Shotaro Otsuka, Takuto Terashi, Kazuki Nakanishi, Koki Ueda, Seiya Takada, Kiyoshi Kikuchi |
| Abstract |
Exercise regimens are established methods that can relieve neuropathic pain. However, the relationship between frequency and intensity of exercise and multiple cellular responses of exercise-induced alleviation of neuropathic pain is still unclear. We examined the influence of exercise frequency on neuropathic pain and the intracellular responses in a sciatic nerve chronic constriction injury (CCI) model. Rats were assigned to four groups as follows: CCI and high-frequency exercise (HFE group), CCI and low-frequency exercise (LFE group), CCI and no exercise (No-Ex group), and naive animals (control group). Rats ran on a treadmill, at a speed of 20 m/min, for 30 min, for 5 (HFE) or 3 (LFE) days a week, for a total of 5 weeks. The 50% withdrawal threshold was evaluated for mechanical sensitivity. The activation of glial cells (microglia and astrocytes), expression of brain-derived neurotrophic factor (BDNF) and μ-opioid receptor in the spinal dorsal horn and endogenous opioid in the midbrain were examined using immunohistochemistry. Opioid receptor antagonists (naloxone) were administered using intraperitoneal injection. The development of neuropathic pain was related to the activation of glial cells, increased BDNF expression, and downregulation of the μ-opioid receptor in the ipsilateral spinal dorsal horn. In the No-Ex group, neuropathic pain showed the highest level of mechanical hypersensitivity at 2 weeks, which improved slightly until 5 weeks after CCI. In both exercise groups, the alleviation of neuropathic pain was accelerated through the regulation of glial activation, BDNF expression, and the endogenous opioid system. The expression of BDNF and endogenous opioid in relation to exercise-induced alleviation of neuropathic pain differed in the HFE and LFE groups. The effects of exercise-induced alleviation of mechanical hypersensitivity were reversed by the administration of naloxone. The LFE and HFE program reduced neuropathic pain. Our findings indicated that aerobic exercise-induced alleviated neuropathic pain through the regulation of glial cell activation, expression of BDNF in the ipsilateral spinal dorsal horn, and the endogenous opioid system. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 23% |
| Spain | 3 | 12% |
| Switzerland | 2 | 8% |
| Qatar | 1 | 4% |
| Chile | 1 | 4% |
| Ireland | 1 | 4% |
| Italy | 1 | 4% |
| Australia | 1 | 4% |
| Germany | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 9 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 81% |
| Scientists | 3 | 12% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 8 | 13% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Postgraduate | 6 | 9% |
| Researcher | 5 | 8% |
| Student > Master | 5 | 8% |
| Other | 11 | 17% |
| Unknown | 22 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 17% |
| Medicine and Dentistry | 7 | 11% |
| Nursing and Health Professions | 6 | 9% |
| Agricultural and Biological Sciences | 3 | 5% |
| Sports and Recreations | 3 | 5% |
| Other | 6 | 9% |
| Unknown | 28 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2019.
All research outputs
#2,179,541
of 24,777,509 outputs
Outputs from Journal of Pain Research
#262
of 1,918 outputs
Outputs of similar age
#50,270
of 450,421 outputs
Outputs of similar age from Journal of Pain Research
#9
of 39 outputs
Altmetric has tracked 24,777,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,918 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.9. This one has done well, scoring higher than 86% of its peers.
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We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.