Title |
Natural products, an important resource for discovery of multitarget drugs and functional food for regulation of hepatic glucose metabolism
|
---|---|
Published in |
Drug Design, Development and Therapy, January 2018
|
DOI | 10.2147/dddt.s151860 |
Pubmed ID | |
Authors |
Jian Li, Haiyang Yu, Sijian Wang, Wei Wang, Qian Chen, Yanmin Ma, Yi Zhang, Tao Wang |
Abstract |
Imbalanced hepatic glucose homeostasis is one of the critical pathologic events in the development of metabolic syndromes (MSs). Therefore, regulation of imbalanced hepatic glucose homeostasis is important in drug development for MS treatment. In this review, we discuss the major targets that regulate hepatic glucose homeostasis in human physiologic and pathophysiologic processes, involving hepatic glucose uptake, glycolysis and glycogen synthesis, and summarize their changes in MSs. Recent literature suggests the necessity of multitarget drugs in the management of MS disorder for regulation of imbalanced glucose homeostasis in both experimental models and MS patients. Here, we highlight the potential bioactive compounds from natural products with medicinal or health care values, and focus on polypharmacologic and multitarget natural products with effects on various signaling pathways in hepatic glucose metabolism. This review shows the advantage and feasibility of discovering multicompound-multitarget drugs from natural products, and providing a new perspective of ways on drug and functional food development for MSs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 33% |
South Africa | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 61 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 21% |
Student > Doctoral Student | 6 | 10% |
Student > Bachelor | 6 | 10% |
Lecturer | 4 | 7% |
Researcher | 4 | 7% |
Other | 12 | 20% |
Unknown | 16 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 12 | 20% |
Biochemistry, Genetics and Molecular Biology | 8 | 13% |
Agricultural and Biological Sciences | 5 | 8% |
Chemistry | 5 | 8% |
Medicine and Dentistry | 5 | 8% |
Other | 6 | 10% |
Unknown | 20 | 33% |