| Title |
Hydrothermal synthesis of nitrogen-doped carbon dots with real-time live-cell imaging and blood–brain barrier penetration capabilities
|
|---|---|
| Published in |
International Journal of Nanomedicine, November 2016
|
| DOI | 10.2147/ijn.s119252 |
| Pubmed ID | |
| Authors |
Shousi Lu, Shanshan Guo, Pingxiang Xu, Xiaorong Li, Yuming Zhao, Wei Gu, Ming Xue |
| Abstract |
Nitrogen-doped carbon dots (N-CDs) were synthesized using a one-pot hydrothermal treatment with citric acid in the presence of polyethylenimine. Transmission electron microscopy analysis revealed that the N-CDs were monodispersed and quasi-spherical with an average size of ~2.6 nm. Under ultraviolet irradiation the N-CDs emitted a strong blue luminescence with a quantum yield as high as 51%. Moreover, the N-CDs exhibited a negligible cytotoxicity and could be applied as efficient nanoprobes for real-time imaging of live cells. In addition, the ability of the N-CDs to cross the blood-brain barrier (BBB) in a concentration-dependent manner was demonstrated using an in vitro BBB model. Therefore, these PEI-passivated N-CDs with real-time live-cell imaging and BBB-penetration capabilities hold promise for traceable drug delivery to the brain. |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 131 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 22% |
| Researcher | 14 | 11% |
| Student > Master | 13 | 10% |
| Student > Bachelor | 10 | 8% |
| Student > Doctoral Student | 7 | 5% |
| Other | 13 | 10% |
| Unknown | 45 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 26 | 20% |
| Materials Science | 15 | 11% |
| Engineering | 10 | 8% |
| Biochemistry, Genetics and Molecular Biology | 7 | 5% |
| Agricultural and Biological Sciences | 6 | 5% |
| Other | 19 | 15% |
| Unknown | 48 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2018.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from International Journal of Nanomedicine
#2,470
of 4,123 outputs
Outputs of similar age
#205,216
of 317,812 outputs
Outputs of similar age from International Journal of Nanomedicine
#60
of 94 outputs
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So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.