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| Title |
NOD2 and inflammation: current insights
|
|---|---|
| Published in |
Journal of Inflammation Research, February 2018
|
| DOI | 10.2147/jir.s137606 |
| Pubmed ID | |
| Authors |
Anna Negroni, Maria Pierdomenico, Salvatore Cucchiara, Laura Stronati |
| Abstract |
The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory transcriptional program and other innate immune pathways, including autophagy and endoplasmic reticulum stress. An inactive form due to mutations or a constitutive high expression of NOD2 is associated with several inflammatory diseases, suggesting that balanced NOD2 signaling is critical for the maintenance of immune homeostasis. In this review, we discuss recent developments about the pathway and mechanisms of regulation of NOD2 and illustrate the principal functions of the gene, with particular emphasis on its central role in maintaining the equilibrium between intestinal microbiota and host immune responses to control inflammation. Furthermore, we survey recent studies illustrating the role of NOD2 in several inflammatory diseases, in particular, inflammatory bowel disease, of which it is the main susceptibility gene. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 283 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 283 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 41 | 14% |
| Student > Bachelor | 38 | 13% |
| Student > Master | 27 | 10% |
| Researcher | 23 | 8% |
| Other | 16 | 6% |
| Other | 33 | 12% |
| Unknown | 105 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 53 | 19% |
| Medicine and Dentistry | 36 | 13% |
| Immunology and Microbiology | 22 | 8% |
| Agricultural and Biological Sciences | 18 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 5% |
| Other | 32 | 11% |
| Unknown | 109 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 June 2021.
All research outputs
#16,123,231
of 25,483,400 outputs
Outputs from Journal of Inflammation Research
#316
of 976 outputs
Outputs of similar age
#255,953
of 449,404 outputs
Outputs of similar age from Journal of Inflammation Research
#9
of 11 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 976 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 63% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.