| Title |
Sex-related differences in effect-site concentration of remifentanil for preventing anesthetic emergence cough in elderly patients
|
|---|---|
| Published in |
Clinical Interventions in Aging, January 2018
|
| DOI | 10.2147/cia.s151476 |
| Pubmed ID | |
| Authors |
Sook Young Lee, Yun Yong Jeong, Byung Ho Lee, Ji Eun Kim |
| Abstract |
Cough on anesthetic emergence should be prevented considering its dangerous complications. Target-controlled infusion (TCI) of remifentanil can reduce emergence cough effectively, and sex-related differences in effect-site concentration (Ce) of remifentanil have been evaluated in young patients. In this study, we determined the Ce of remifentanil for preventing emergence cough following extubation in male and female elderly patients and evaluated the sex-related difference. Twenty-three male and 22 female elderly patients aged between 60 and 75 years were enrolled. Anesthesia was maintained with sevoflurane and remifentanil TCI. The Ce of remifentanil for preventing emergence cough was determined for each sex using isotonic regression method with a bootstrapping approach, following Dixon's up-and-down method. The Ce of remifentanil for preventing emergence cough in 50% (EC50) and 95% (EC95) of the population was significantly lower in females than in males. Isotonic regression revealed the EC50 (83% confidence interval [CI]) of remifentanil was 1.67 (1.55-1.83) ng/mL in females and 2.60 (2.29-2.91) ng/mL in males. The EC95 (95% CI) of remifentanil was 2.30 (2.02-2.62) ng/mL in females and 3.41 (3.27-3.58) ng/mL in males. Dixon's up-and-down method indicated that the mean EC50 in females was lower than in males (1.56±0.26 ng/mL vs 2.56±0.37 ng/mL, P<0.001). The remifentanil requirement for preventing emergence cough was lower in female than in male elderly patients, indicative of sex-related differences in Ce of remifentanil. Sex should be considered when using remifentanil TCI for preventing emergence cough in elderly patients. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Spain | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 19% |
| Student > Bachelor | 2 | 13% |
| Lecturer | 1 | 6% |
| Student > Doctoral Student | 1 | 6% |
| Librarian | 1 | 6% |
| Other | 3 | 19% |
| Unknown | 5 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 19% |
| Medicine and Dentistry | 3 | 19% |
| Nursing and Health Professions | 2 | 13% |
| Sports and Recreations | 1 | 6% |
| Unknown | 7 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2018.
All research outputs
#14,605,790
of 25,382,440 outputs
Outputs from Clinical Interventions in Aging
#934
of 1,968 outputs
Outputs of similar age
#222,611
of 449,550 outputs
Outputs of similar age from Clinical Interventions in Aging
#20
of 44 outputs
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