| Title |
The role of calgranulin B gene on the biological behavior of squamous cervical cancer in vitro and in vivo
|
|---|---|
| Published in |
Cancer Management and Research, February 2018
|
| DOI | 10.2147/cmar.s153036 |
| Pubmed ID | |
| Authors |
Wenwen Zhang, Miaomiao Chen, Huihui Cheng, Qi Shen, Ying Wang, Xueqiong Zhu |
| Abstract |
The objective of the study was to explore the role ofcalgranulin Bgene on the biological behavior of squamous cervical cancer. Differential transcription incalgranulin Bgene between human papillomavirus (HPV)-positive and negative cervical cancer groups was identified, and the relationship betweencalgranulin Bgene andmatrix metalloproteinase(MMP) genes were explored using The Cancer Genome Atlas database. Subsequently, the role of calgranulin B on the cell proliferation, apoptosis, invasion and migration was investigated, through overexpression and/or underexpression of calgranulin B in cervical cancer cells. In addition, the effect of calgranulin B on the growth of the cervical cancer was studied via constructing xenograft model in BALB/c nude mice that either overexpressed or underexpressed calgranulin B. Calgranulin B gene transcription in cervical cancer was highly correlated with the high-risk HPV-16 and HPV-45. In addition, overexpression of calgranulin B increased cell proliferation, invasion and migration, whereas it did not significantly affect cell apoptosis. This effect was also confirmed by calgranulin B knockdown assay. Additionally, we found that the transcription ofcalgranulin Bgene was negatively correlated withMMP15andMMP24genes, but positively associated withMMP25genes in cervical cancer. Furthermore, calgranulin B significantly promoted the growth of cervical cancer in vivo. Calgranulin B promotes cell proliferation, migration and invasion of squamous cervical cancer, possibly via regulation of MMPs. Whether there are synergistic actions between calgranulin B and HPV-16/HPV-45 infection on the squamous cervical carcinogenesis or progression need further study. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 60% |
| Researcher | 1 | 20% |
| Lecturer > Senior Lecturer | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 40% |
| Agricultural and Biological Sciences | 1 | 20% |
| Immunology and Microbiology | 1 | 20% |
| Medicine and Dentistry | 1 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2018.
All research outputs
#18,587,406
of 23,023,224 outputs
Outputs from Cancer Management and Research
#1,056
of 2,016 outputs
Outputs of similar age
#329,676
of 440,124 outputs
Outputs of similar age from Cancer Management and Research
#33
of 43 outputs
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