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The distribution of blood eosinophil levels in a Japanese COPD clinical trial database and in the rest of the world

Overview of attention for article published in International Journal of Chronic Obstructive Pulmonary Disease, February 2018
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Title
The distribution of blood eosinophil levels in a Japanese COPD clinical trial database and in the rest of the world
Published in
International Journal of Chronic Obstructive Pulmonary Disease, February 2018
DOI 10.2147/copd.s144108
Pubmed ID
Authors

Neil Barnes, Takeo Ishii, Nobuyuki Hizawa, Dawn Midwinter, Mark James, Emma Hilton, Paul Jones

Abstract

Blood eosinophil measurements may help to guide physicians on the use of inhaled corticosteroids (ICS) for patients with chronic obstructive pulmonary disease (COPD). Emerging data suggest that COPD patients with higher blood eosinophil counts may be at higher risk of exacerbations and more likely to benefit from combined ICS/long-acting beta2-agonist (LABA) treatment than therapy with a LABA alone. This analysis describes the distribution of blood eosinophil count at baseline in Japanese COPD patients in comparison with non-Japanese COPD patients. A post hoc analysis of eosinophil distribution by percentage and absolute cell count was performed across 12 Phase II-IV COPD clinical studies (seven Japanese studies [N=848 available absolute eosinophil counts] and five global studies [N=5,397 available eosinophil counts] that included 246 Japanese patients resident in Japan with available counts). Blood eosinophil distributions were assessed at baseline, before blinded treatment assignment. Among Japanese patients, the median (interquartile range) absolute eosinophil count was 170 cells/mm3(100-280 cells/mm3). Overall, 612/1,094 Japanese patients (56%) had an absolute eosinophil count ≥150 cells/mm3and 902/1,304 Japanese patients (69%) had a percentage eosinophil ≥2%. Among non-Japanese patients, these values were 160 (100-250) cells/mm3, 2,842/5,151 patients (55%), and 2,937/5,155 patients (57%), respectively. The eosinophil distribution among Japanese patients was similar to that among non-Japanese patients. Within multi-country studies with similar inclusion criteria, the eosinophil count was numerically lower in Japanese compared with non-Japanese patients (median 120 vs 160 cells/mm3). The eosinophil distribution in Japanese patients seems comparable to that of non-Japanese patients; although within multi-country studies, there was a slightly lower median eosinophil count for Japanese patients compared with non-Japanese patients. These findings suggest that blood eosinophil data from global studies are of relevance in Japan.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 24%
Researcher 2 12%
Student > Bachelor 2 12%
Student > Master 2 12%
Professor 1 6%
Other 3 18%
Unknown 3 18%
Readers by discipline Count As %
Medicine and Dentistry 9 53%
Sports and Recreations 1 6%
Computer Science 1 6%
Chemistry 1 6%
Agricultural and Biological Sciences 1 6%
Other 0 0%
Unknown 4 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2018.
All research outputs
#10,023,848
of 12,526,930 outputs
Outputs from International Journal of Chronic Obstructive Pulmonary Disease
#1,225
of 1,529 outputs
Outputs of similar age
#201,919
of 270,947 outputs
Outputs of similar age from International Journal of Chronic Obstructive Pulmonary Disease
#48
of 53 outputs
Altmetric has tracked 12,526,930 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,529 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,947 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.