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MiR-1180-5p regulates apoptosis of Wilms’ tumor by targeting p73

Overview of attention for article published in OncoTargets and therapy, February 2018
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Title
MiR-1180-5p regulates apoptosis of Wilms&rsquo; tumor by targeting<em> p</em>73
Published in
OncoTargets and therapy, February 2018
DOI 10.2147/ott.s148684
Pubmed ID
Authors

Xiuyun Jiang, Huaicheng Li

Abstract

Wilms' tumor (WT), the most common childhood tumor, occurs in sporadic or familial forms. Recent findings reported that abnormal expression in microRNA (miRNA) suggests an important role of miRNAs during WT progress. MiRNAs are endogenous short-chain noncoding RNAs, which have been reported as key biomarkers for detecting tumor onset and progression. However, the functional role of miR-1180 in WT has remained unknown. MTT and clonogenic survival assays were used to detect WT cell proliferation. Flow cytometry Annexin V-FITC was used to measure apoptosis. In addition, proteins expressions in the cells were determined by Western blotting. In the present study, we demonstrated that miR-1180 is upregulated in WT when compared with adjacent tissues by quantitative reverse-transcription polymerase chain reaction. In addition, the inhibition of miR-1180 induced apoptosis in SK-NEP-1 cell line in vitro. Moreover, luciferase reporter assay showed thatp73protein was the target of miR-1180, which was confirmed by the results of Western blotting. Finally, in vivo data indicated that the tumor growth in mice was significantly inhibited by miR-1180 inhibitor. Our results indicate that miR-1180 might serve as a therapeutic target for future WT therapy.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Unknown 4 100%
Readers by discipline Count As %
Unknown 4 100%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 February 2018.
All research outputs
#10,032,597
of 12,538,691 outputs
Outputs from OncoTargets and therapy
#813
of 1,564 outputs
Outputs of similar age
#202,323
of 271,234 outputs
Outputs of similar age from OncoTargets and therapy
#31
of 48 outputs
Altmetric has tracked 12,538,691 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,564 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
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We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.