| Title |
Origanum vulgare mediated green synthesis of biocompatible gold nanoparticles simultaneously possessing plasmonic, antioxidant and antimicrobial properties
|
|---|---|
| Published in |
International Journal of Nanomedicine, February 2018
|
| DOI | 10.2147/ijn.s149819 |
| Pubmed ID | |
| Authors |
Daniela Benedec, Ilioara Oniga, Flavia Cuibus, Bogdan Sevastre, Gabriela Stiufiuc, Mihaela Duma, Daniela Hanganu, Cristian Iacovita, Rares Stiufiuc, Constantin Mihai Lucaciu |
| Abstract |
The leaves and flowering stem ofOriganum vulgarecontain essential oils, flavonoids, phenolic acids and anthocyanins. We propose a new, simple, one-pot,O. vulgareextract (OVE) mediated green synthesis method of biocompatible gold nanoparticles (AuNPs) possessing improved antioxidant, antimicrobial and plasmonic properties. Different concentrations of OVEs were used to reduce gold ions and to synthetize biocompatible spherical AuNPs. Their morphology and physical properties have been investigated by means of transmission electron microscopy, ultraviolet-visible absorption spectroscopy, photon correlation spectroscopy and Fourier transform infrared spectroscopy, whereas their plasmonic properties have been tested using surface-enhanced Raman spectroscopy (SERS). The antioxidant properties of nanoparticles (NPs) have been evaluated by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, and the antimicrobial tests were performed using the disk diffusion assay. Their cytotoxicity has been assessed by means of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The experimental results confirmed the successful synthesis of biocompatible, spherical, plasmonic NPs having a mean diameter of ~40 nm and an outstanding aqueous stability. This new class of NPs exhibits a very good antioxidant activity and presents interesting inhibitory effects againstStaphylococcus aureusandCandida albicans. Due to their plasmonic properties, AuNPs are used as SERS substrates for the detection of a test molecule (methylene blue) up to a concentration of 10-7M and a pharmaceutical compound (propranolol) in solution. Cytotoxicity assays revealed that AuNPs are better tolerated by normal human dermal fibroblast cells, while the melanoma cancer cells are more sensitive. The biocompatible AuNPs synthetized using OVEs showed significant bactericidal and antimycotic activities, the most sensitive microorganisms beingS. aureusandC. albicans, both commonly involved in various dermatological infections. Moreover, the significant antioxidant effect might recommend their use for protective and/or preventive effect in various skin inflammatory conditions, including the reduction in side effects in dermatological infections. Meanwhile, the as-synthesized biocompatible AuNPs can be successfully used as SERS substrates for the detection of pharmaceutical compounds in aqueous solutions. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 15 | 12% |
| Student > Bachelor | 13 | 10% |
| Researcher | 12 | 9% |
| Student > Ph. D. Student | 11 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Other | 17 | 13% |
| Unknown | 50 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 16 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 9% |
| Agricultural and Biological Sciences | 12 | 9% |
| Medicine and Dentistry | 9 | 7% |
| Biochemistry, Genetics and Molecular Biology | 5 | 4% |
| Other | 17 | 13% |
| Unknown | 56 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2018.
All research outputs
#15,097,241
of 25,382,440 outputs
Outputs from International Journal of Nanomedicine
#1,655
of 4,122 outputs
Outputs of similar age
#233,601
of 448,849 outputs
Outputs of similar age from International Journal of Nanomedicine
#30
of 83 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,122 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
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We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.