Title |
Treatment of adult-onset Still’s disease: a review
|
---|---|
Published in |
Therapeutics and Clinical Risk Management, December 2014
|
DOI | 10.2147/tcrm.s64951 |
Pubmed ID | |
Authors |
Yvan Jamilloux, Mathieu Gerfaud-Valentin, Thomas Henry, Pascal Sève |
Abstract |
Adult-onset Still's disease (AOSD) is a rare inflammatory disorder that has been recently classified as a polygenic autoinflammatory disorder. The former classification, based on the disease course, seems to be quite dated. Indeed, there is accumulating evidence that AOSD can be divided into two distinct phenotypes based on cytokine profile, clinical presentation, and outcome, ie, a "systemic" pattern and an "articular" pattern. The first part of this review deals with the treatments that are currently available for AOSD. We then present the different strategies based on the characteristics of the disease according to clinical presentation. To do so, we focus on the two subsets of the disease. Finally, we discuss the management of life-threatening complications of AOSD, along with the therapeutic options during pregnancy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 20% |
Germany | 1 | 10% |
Mexico | 1 | 10% |
Spain | 1 | 10% |
Sweden | 1 | 10% |
Singapore | 1 | 10% |
Unknown | 3 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 80% |
Scientists | 1 | 10% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | <1% |
Italy | 1 | <1% |
Unknown | 118 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 22 | 18% |
Student > Ph. D. Student | 13 | 11% |
Researcher | 13 | 11% |
Student > Bachelor | 11 | 9% |
Student > Master | 11 | 9% |
Other | 29 | 24% |
Unknown | 21 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 70 | 58% |
Immunology and Microbiology | 7 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 3% |
Agricultural and Biological Sciences | 3 | 3% |
Other | 7 | 6% |
Unknown | 25 | 21% |