| Title |
Carriage of colistin-resistant, extended-spectrum β-lactamase-producing Escherichia coli harboring the mcr-1 resistance gene after short-term international travel to Vietnam
|
|---|---|
| Published in |
Infection and Drug Resistance, March 2018
|
| DOI | 10.2147/idr.s153178 |
| Pubmed ID | |
| Authors |
Tatsuya Nakayama, Yuko Kumeda, Ryuji Kawahara, Takahiro Yamaguchi, Yoshimasa Yamamoto |
| Abstract |
Due to increasing colistin usage, the dissemination of the colistin-resistant genemcr-1has been increasingly investigated. The aim of this study was to determine whether a traveler on a short-term international trip to a developing country could bringmcr-1back to their home country. Thirty-four travel events from Japan to Vietnam encompassing 19 travelers were assessed. A fecal specimen was collected from each traveler before and after each travel event and was inoculated on CHROMagar containing cefotaxime (CTX). Three to seven colonies exhibiting the characteristics ofEscherichia coliwere collected. Susceptibility to antibiotics and extended-spectrum β-lactamase (ESBL) production were determined by the disk diffusion method and the double-disk synergy test, respectively. ESBL-encoding genes were genotyped, and phylogenetic groupings were determined by multiplex polymerase chain reaction (PCR). The presence ofmcr-1was also confirmed by PCR and sequencing. A total of 175 ESBL-producingE. coliisolated before and up to 2 weeks after traveling to Vietnam were analyzed. Genotyping of ESBL-producing isolates showed thatblaCTX-M-1/blaTEM(27.7%) andblaCTX-M-9(45.9%) were the most prevalent genotypes, while the most frequently detected phylogenetic group was D (41.9%) followed by B2 (23.0%). In a significant number of travel events, travelers brought ESBL-producingE. coliback to Japan and three events by three travelers carriedmcr-1. ESBL-producingE. coliisolates harboringmcr-1were identified as those carrying bothblaCTX-M-14orblaCTX-M-55andmcr-1. Using Vietnam as an example, we have shown that even a short-term trip to some countries may result in ESBL-producingmcr-1-positiveE. colicarriage by international travelers. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 60 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 20% |
| Student > Bachelor | 8 | 13% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Master | 6 | 10% |
| Other | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 19 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 8 | 13% |
| Medicine and Dentistry | 8 | 13% |
| Veterinary Science and Veterinary Medicine | 6 | 10% |
| Agricultural and Biological Sciences | 4 | 7% |
| Nursing and Health Professions | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 24 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2018.
All research outputs
#572,772
of 23,026,672 outputs
Outputs from Infection and Drug Resistance
#16
of 1,686 outputs
Outputs of similar age
#14,695
of 331,163 outputs
Outputs of similar age from Infection and Drug Resistance
#1
of 35 outputs
Altmetric has tracked 23,026,672 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,686 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 99% of its peers.
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We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.