| Title |
Repetitive transcranial magnetic stimulation for the treatment of cognitive impairment in frontotemporal dementia: an open-label pilot study
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, March 2018
|
| DOI | 10.2147/ndt.s153213 |
| Pubmed ID | |
| Authors |
Jakub Antczak, Katarzyna Kowalska, Aleksandra Klimkowicz-Mrowiec, Barbara Wach, Katarzyna Kasprzyk, Marta Banach, Karolina Rzeźnicka-Brzegowy, Jadwiga Kubica, Agnieszka Słowik |
| Abstract |
Frontotemporal dementia (FTD) is one of the most frequent dementia types in patients under 65 years of age. Currently, no therapy can effectively improve the cognitive deficits associated with FTD. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method of inducing brain plasticity with therapeutic potential in neurodegenerative diseases. The purpose of this study was to evaluate the effect of rTMS on cognitive, behavioral, and emotional function in FTD. Nine patients (seven women, four men, mean age 61.7±10.1 years) with the behavioral variant of FTD, one with nonfluent/agrammatic variant primary progressive aphasia, and one with progressive nonfluent aphasia (subtypes of FTD) underwent 10 daily sessions of 10 Hz rTMS over the bilateral dorsolateral prefrontal cortex. Cognitive and behavioral assessments were administered before and after therapy. After rTMS, the Montreal Cognitive Assessment and letter and digit cancellation test scores, as well as reading time and error number in the Stroop test improved. The caregivers' impression of the daily functioning of patients improved in the Frontal Behavioral Inventory scores. These changes were not paralleled by an improvement of mood. The results indicate that rTMS may improve the cognitive performance of patients with FTD and warrant sham-controlled trials. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 117 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 15% |
| Student > Bachelor | 16 | 14% |
| Researcher | 11 | 9% |
| Student > Ph. D. Student | 9 | 8% |
| Other | 8 | 7% |
| Other | 21 | 18% |
| Unknown | 35 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 23 | 20% |
| Neuroscience | 15 | 13% |
| Medicine and Dentistry | 13 | 11% |
| Nursing and Health Professions | 11 | 9% |
| Agricultural and Biological Sciences | 5 | 4% |
| Other | 6 | 5% |
| Unknown | 44 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 December 2022.
All research outputs
#2,175,393
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#271
of 3,131 outputs
Outputs of similar age
#45,660
of 344,853 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#8
of 76 outputs
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