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First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study

Overview of attention for article published in International Medical Case Reports Journal, March 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#2 of 171)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

news
8 news outlets
twitter
8 tweeters
video
1 video uploader

Readers on

mendeley
19 Mendeley
Title
First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study
Published in
International Medical Case Reports Journal, March 2018
DOI 10.2147/imcrj.s163612
Pubmed ID
Authors

Kristin Comella, Michelle Parlo, Rosemary Daly, Kellie Dominessy

Abstract

Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 16%
Student > Doctoral Student 3 16%
Other 2 11%
Student > Bachelor 2 11%
Student > Master 1 5%
Other 2 11%
Unknown 6 32%
Readers by discipline Count As %
Medicine and Dentistry 3 16%
Biochemistry, Genetics and Molecular Biology 3 16%
Energy 1 5%
Psychology 1 5%
Nursing and Health Professions 1 5%
Other 4 21%
Unknown 6 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 71. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2018.
All research outputs
#257,689
of 14,056,097 outputs
Outputs from International Medical Case Reports Journal
#2
of 171 outputs
Outputs of similar age
#10,922
of 277,218 outputs
Outputs of similar age from International Medical Case Reports Journal
#1
of 6 outputs
Altmetric has tracked 14,056,097 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 171 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,218 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them