| Title |
Aberrant regional brain activities in alcohol dependence: a functional magnetic resonance imaging study
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, March 2018
|
| DOI | 10.2147/ndt.s158221 |
| Pubmed ID | |
| Authors |
Xianzhu Tu, Juanjuan Wang, Xuming Liu, Jiyong Zheng |
| Abstract |
Whether moderate alcohol consumption has health benefits remains controversial, but the harmful effects of excessive alcohol consumption on behavior and brain function are well recognized. The aim of this study was to investigate alcohol-induced regional brain activities and their relationships with behavioral factors. A total of 29 alcohol-dependent subjects (9 females and 20 males) and 29 status-matched healthy controls (11 females and 18 males) were recruited. Severity of alcohol dependence questionnaire (SADQ) and alcohol use disorders identification test (AUDIT) were used to evaluate the severity of alcohol craving. Regional homogeneity (ReHo) analysis was used to explore the alcohol-induced regional brain changes. Receiver operating characteristic (ROC) curve was used to investigate the ability of regional brain activities to distinguish alcohol-dependent subjects from healthy controls. Pearson correlations were used to investigate the relationships between alcohol-induced ReHo differences and behavioral factors. Alcohol-dependent subjects related to healthy controls showed higher ReHo areas in the right superior frontal gyrus (SFG), bilateral medial frontal gyrus (MFG), left precentral gyrus (PG), bilateral middle temporal gyrus (MTG), and right inferior temporal gyrus (ITG) and lower ReHo areas in the right cerebellum posterior lobe (CPL), left rectal gyrus (RG), and right cluster of pons and cerebellum anterior lobe (CAL). ROC curve revealed high area under the curve (AUC) values (mean ± SD: 0.864 ± 0.028; range: 0.828-0.911) of ReHo differences. Diagnostic analysis showed that these areas alone discriminated alcohol-dependent subjects from healthy controls with high degree of sensitivities (mean ± SD: 81.25% ± 11.49%; range: 62.5%-100%) and specificities (mean ± SD: 81.75% ± 12.36%; range: 67.5%-100%). Years of drink showed negative correlation with left RG (r = -0.493, p = 0.007), the same finding was shown between AUDIT and right CPL (r = -0.52, p = 0.004). Alcohol dependence is associated with aberrant regional activities in multiple brain areas. ReHo analysis may be a useful biological indicator for the detection of regional brain activities in individuals with alcohol dependence. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 9% |
| Researcher | 2 | 9% |
| Student > Postgraduate | 2 | 9% |
| Student > Master | 2 | 9% |
| Lecturer > Senior Lecturer | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 11 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 5 | 22% |
| Neuroscience | 3 | 13% |
| Unspecified | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Mathematics | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 10 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2018.
All research outputs
#15,745,807
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,506
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Outputs of similar age
#193,349
of 344,853 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#26
of 76 outputs
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