| Title |
Comparative effectiveness of switching paroxetine formulation for treatment of major depressive disorder: an open-label multicenter study
|
|---|---|
| Published in |
Neuropsychiatric Disease and Treatment, April 2018
|
| DOI | 10.2147/ndt.s152985 |
| Pubmed ID | |
| Authors |
Tempei Otsubo, Yoshinori Watanabe, Seiji Hongo, Mikichika Inoue, Kimiko Akimoto, Ken Murakami, Ryutaro Takahashi, Toshiaki Kikuchi |
| Abstract |
To assess the effectiveness and safety of switching the antidepressant formulation from immediate-release (IR) to controlled-release (CR) paroxetine in patients with major depressive disorder (MDD). A total of 113 outpatients with MDD diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, and treated with a stable dose of IR paroxetine for at least 6 months were enrolled. Patients were then switched to CR paroxetine for 8 weeks. Effectiveness was evaluated by scores on the Himorogi Self-Rating Depression/Anxiety Scales (HSDS/HSAS) and the Clinical Global Impression - Severity (CGI-S). Safety was evaluated based on the reported adverse drug reactions (ADRs). Medication satisfaction and preference were assessed based on questionnaire responses using Likert-type scales. The overall patient HSDS/HSAS scores significantly improved after switching from IR to CR paroxetine (P<0.001). Furthermore, CR paroxetine was superior to IR paroxetine (P<0.001) according to the results of the CGI-S evaluation. ADRs were experienced by 14 (12.4%) patients, including dry mouth, nausea/vomiting, somnolence/drowsiness, and wakefulness/arousal during sleep. Satisfaction and preference for paroxetine improved after switching to the CR formulation (P<0.001; chi-square test). These results suggest that switching the treatment from IR to CR paroxetine could improve depressive symptoms and decrease ADRs. However, these results may have been caused by the psychological effect of drug switching. Hence, future studies with blinded evaluation methods are required to confirm and expand our findings. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 23% |
| Student > Doctoral Student | 4 | 18% |
| Student > Bachelor | 3 | 14% |
| Other | 2 | 9% |
| Student > Master | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 7 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 5 | 23% |
| Medicine and Dentistry | 4 | 18% |
| Nursing and Health Professions | 2 | 9% |
| Agricultural and Biological Sciences | 1 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Other | 2 | 9% |
| Unknown | 7 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2018.
All research outputs
#16,584,977
of 25,382,440 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,712
of 3,131 outputs
Outputs of similar age
#208,682
of 343,807 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#37
of 77 outputs
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