| Title |
Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers
|
|---|---|
| Published in |
Vascular Health and Risk Management, June 2008
|
| DOI | 10.2147/vhrm.s1991 |
| Pubmed ID | |
| Authors |
Camelia R Ban, Stephen M Twigg |
| Abstract |
Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One pathological response to tissue injury is the development of fibrosis, which involves predominant extracellular matrix (ECM) accumulation. The main factors that regulate ECM in diabetes are thought to be pro-sclerotic cytokines and protease/anti-protease systems. This review will examine the key markers and regulators of tissue fibrosis in diabetes and whether their levels in biological fluids may have clinical utility. |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| India | 1 | <1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| Thailand | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 197 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 46 | 23% |
| Researcher | 37 | 18% |
| Student > Master | 32 | 16% |
| Student > Bachelor | 13 | 6% |
| Professor | 10 | 5% |
| Other | 37 | 18% |
| Unknown | 28 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 56 | 28% |
| Agricultural and Biological Sciences | 34 | 17% |
| Biochemistry, Genetics and Molecular Biology | 28 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 7% |
| Engineering | 5 | 2% |
| Other | 27 | 13% |
| Unknown | 38 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2021.
All research outputs
#2,864,597
of 25,377,790 outputs
Outputs from Vascular Health and Risk Management
#88
of 804 outputs
Outputs of similar age
#8,444
of 97,662 outputs
Outputs of similar age from Vascular Health and Risk Management
#5
of 16 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 804 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 97,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.