| Title |
Calcium sparks in the heart: dynamics and regulation
|
|---|---|
| Published in |
Research and reports in biology, October 2015
|
| DOI | 10.2147/rrb.s61495 |
| Pubmed ID | |
| Authors |
Tuan M Hoang-Trong, Aman Ullah, M Saleet Jafri |
| Abstract |
Calcium (Ca2+) plays a central role in the contraction of the heart. It is the bi-directional link between electrical excitation of the heart and contraction. Electrical excitation initiates Ca2+influx across the sarcolemma and T-tubular membrane that triggered calcium release from the sarcoplasmic reticulum. Ca2+sparks are the elementary events of calcium release from the sarcoplasmic reticulum. Therefore, understanding the dynamics of Ca2+sparks is essential for understanding the function of the heart. To this end, numerous experimental and computational studies have focused on this topic, exploring the mechanisms of calcium spark initiation, termination, and regulation and what role these play in normal and patho-physiology. The proper understanding of Ca2+ spark regulation and dynamics serves as the foundation for our insights into a multitude of pathological conditions may develop that can be the result of structural and/or functional changes at the cellular or subcellular level. Computational modeling of Ca2+ spark dynamics has proven to be a useful tool to understand Ca2+ spark dynamics. This review addresses our current understanding of Ca2+ sparks and how synchronized SR Ca2+ release, in which Ca2+ sparks is a major pathway, is linked to the different cardiac diseases, especially arrhythmias. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 68 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 23% |
| Student > Bachelor | 13 | 19% |
| Student > Master | 10 | 14% |
| Researcher | 8 | 12% |
| Other | 5 | 7% |
| Other | 9 | 13% |
| Unknown | 8 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 23% |
| Medicine and Dentistry | 12 | 17% |
| Agricultural and Biological Sciences | 8 | 12% |
| Neuroscience | 4 | 6% |
| Mathematics | 3 | 4% |
| Other | 14 | 20% |
| Unknown | 12 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2020.
All research outputs
#17,302,400
of 25,394,764 outputs
Outputs from Research and reports in biology
#13
of 21 outputs
Outputs of similar age
#171,676
of 286,963 outputs
Outputs of similar age from Research and reports in biology
#5
of 7 outputs
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