| Title |
The role of miR-29b in cancer: regulation, function, and signaling
|
|---|---|
| Published in |
OncoTargets and therapy, March 2015
|
| DOI | 10.2147/ott.s75899 |
| Pubmed ID | |
| Authors |
Bin Yan, Qiong Guo, Fa-jun Fu, Zhao Wang, Zhuo Yin, Yong-bao Wei, Jin-rui Yang |
| Abstract |
MicroRNAs (miRNAs) are endogenous small non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. The miRNA-29 family consists of miR-29a, miR-29b, and miR-29c, among which miR-29b is the most highly expressed and is found at two genomic loci. Recently, numerous studies have demonstrated that aberrant expression of miR-29b is common in the majority of human cancers. miR-29b is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as an oncogene under certain conditions. In this review, we illustrate the role of miR-29b in cancer regulation, function, and signaling. This is the first review highlighting the role of miR-29b in cancer. Our review aims to summarize the effects of miR-29b on cancer activity and its interactions with target genes and signaling pathways, as well as to provide therapeutic implications for overcoming cancer chemoresistance. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Austria | 1 | <1% |
| Unknown | 122 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 16% |
| Student > Master | 20 | 16% |
| Researcher | 18 | 15% |
| Student > Bachelor | 17 | 14% |
| Student > Doctoral Student | 7 | 6% |
| Other | 15 | 12% |
| Unknown | 27 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 40 | 32% |
| Agricultural and Biological Sciences | 21 | 17% |
| Medicine and Dentistry | 16 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Immunology and Microbiology | 3 | 2% |
| Other | 10 | 8% |
| Unknown | 28 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2015.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from OncoTargets and therapy
#2,078
of 3,016 outputs
Outputs of similar age
#232,488
of 270,992 outputs
Outputs of similar age from OncoTargets and therapy
#20
of 26 outputs
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