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Peptide gH625 enters into neuron and astrocyte cell lines and crosses the blood–brain barrier in rats

Overview of attention for article published in International Journal of Nanomedicine, March 2015
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Title
Peptide gH625 enters into neuron and astrocyte cell lines and crosses the blood–brain barrier in rats
Published in
International Journal of Nanomedicine, March 2015
DOI 10.2147/ijn.s77734
Pubmed ID
Authors

Salvatore Valiante, Annarita Falanga, Luisa Cigliano, Giuseppina Iachetta, Rosa Anna Busiello, Valeria La Marca, Massimiliano Galdiero, Assunta Lombardi, Stefania Galdiero

Abstract

Peptide gH625, derived from glycoprotein H of herpes simplex virus type 1, can enter cells efficiently and deliver a cargo. Nanoparticles armed with gH625 are able to cross an in vitro model of the blood-brain barrier (BBB). In the present study, in vitro experiments were performed to investigate whether gH625 can enter and accumulate in neuron and astrocyte cell lines. The ability of gH625 to cross the BBB in vivo was also evaluated. gH625 was administered in vivo to rats and its presence in the liver and in the brain was detected. Within 3.5 hours of intravenous administration, gH625 can be found beyond the BBB in proximity to cell neurites. gH625 has no toxic effects in vivo, since it does not affect the maximal oxidative capacity of the brain or the mitochondrial respiration rate. Our data suggest that gH625, with its ability to cross the BBB, represents a novel nanocarrier system for drug delivery to the central nervous system. These results open up new possibilities for direct delivery of drugs into patients in the field of theranostics and might address the treatment of several human diseases.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 27%
Student > Ph. D. Student 10 22%
Student > Bachelor 4 9%
Student > Master 3 7%
Student > Doctoral Student 2 4%
Other 7 16%
Unknown 7 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 27%
Biochemistry, Genetics and Molecular Biology 6 13%
Engineering 5 11%
Chemistry 4 9%
Neuroscience 3 7%
Other 7 16%
Unknown 8 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2015.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from International Journal of Nanomedicine
#2,469
of 4,123 outputs
Outputs of similar age
#163,954
of 270,992 outputs
Outputs of similar age from International Journal of Nanomedicine
#46
of 77 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,123 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,992 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.