| Title |
Improvement of skin condition in striae distensae: development, characterization and clinical efficacy of a cosmetic product containing Punica granatum seed oil and Croton lechleri resin extract
|
|---|---|
| Published in |
Drug Design, Development and Therapy, February 2017
|
| DOI | 10.2147/dddt.s128470 |
| Pubmed ID | |
| Authors |
Cătălina Bogdan, Sonia Iurian, Ioan Tomuta, Mirela Moldovan |
| Abstract |
Striae distensae are a frequent skin condition associated with pregnancy, weight change or lack of skin elasticity. The aim of this research was to obtain a topical product containing herbal active ingredients with documented antioxidant and anti-inflammatory activity (Punica granatum seed oil and Croton lechleri resin extract) and demonstrate its positive effect on prevention and treatment of striae distensae. First, the cream base formulation was optimized through experimental design. Secondly, the cream containing the two active ingredients was investigated in an interventional nonrandomized clinical trial. The clinical outcome was assessed through biophysical parameters and ultrasonographic evaluation. The state of the skin was evaluated by biophysical measurements and ultrasonography at the beginning of the study and after 3 and 6 weeks. The experimental design was successfully used to set the best ranges for the technological and formulation factors to obtain a cosmetic formulation with optimal characteristics. The study of clinical efficacy on the optimal formulation revealed an increase in the dermis thickness, hydration and elasticity values in both groups after 6 weeks of cream application. The new oil-in-water cream containing P. granatum seed oil and C. lechleri resin extract can be helpful in the prevention or improving of skin changes associated with striae. |
Mendeley readers
The data shown below were compiled from readership statistics for 143 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 143 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 17% |
| Researcher | 14 | 10% |
| Student > Master | 11 | 8% |
| Student > Ph. D. Student | 7 | 5% |
| Student > Postgraduate | 7 | 5% |
| Other | 21 | 15% |
| Unknown | 58 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 26 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 21 | 15% |
| Agricultural and Biological Sciences | 12 | 8% |
| Nursing and Health Professions | 5 | 3% |
| Chemistry | 5 | 3% |
| Other | 14 | 10% |
| Unknown | 60 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2019.
All research outputs
#4,761,537
of 25,382,440 outputs
Outputs from Drug Design, Development and Therapy
#291
of 2,268 outputs
Outputs of similar age
#89,538
of 424,972 outputs
Outputs of similar age from Drug Design, Development and Therapy
#8
of 45 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,268 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,972 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.