Title |
A pilot study of acotiamide hydrochloride hydrate in patients with detrusor underactivity
|
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Published in |
Research and Reports in Urology, May 2015
|
DOI | 10.2147/rru.s83309 |
Pubmed ID | |
Authors |
Koichi Sugimoto, Takahiro Akiyama, Nobutaka Shimizu, Naoki Matsumura, Taiji Hayashi, Tsukasa Nishioka, Hirotsugu Uemura |
Abstract |
To investigate the clinical efficacy of acotiamide hydrochloride hydrate in patients with detrusor underactivity. We measured the post-void residual urinary volume in 19 patients with underactive bladders. All these patients had been under treatment with distigmine bromide and were prescribed acotiamide hydrochloride hydrate at a dose of 100 mg three times daily for 2 weeks. Compared with the post-void residual urinary volume value at baseline (161.4±90.0 mL) a statistically significant reduction was observed at the end of treatment (116.3±63.1 mL) (P=0.006). The drug was generally well tolerated by the majority of patients. Maybe, acotiamide hydrochloride hydrate showed clinical efficacy in patients with underactive bladders and may, therefore, be used alternatively in patients who do not respond sufficiently to distigmine bromide. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 11 | 100% |
Demographic breakdown
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Researcher | 3 | 27% |
Student > Master | 2 | 18% |
Other | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Student > Doctoral Student | 1 | 9% |
Other | 2 | 18% |
Unknown | 1 | 9% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 18% |
Agricultural and Biological Sciences | 1 | 9% |
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