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Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs

Overview of attention for article published in International Journal of Nanomedicine, May 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

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5 tweeters

Citations

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32 Dimensions

Readers on

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26 Mendeley
Title
Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs
Published in
International Journal of Nanomedicine, May 2015
DOI 10.2147/ijn.s82481
Pubmed ID
Authors

Yihui Deng, Chunling Wang, Xiaobo Cheng, Yuqing Su, Ying Pei, Yanzhi Song, Jiao, Zhenjun Huang, Yanfei Ma, Yinming Dong, Ying Yao, Jingjing Fan, Han Ta, Xinrong Liu, Hui Xu

Abstract

The cross-administration of nanocarriers modified by poly(ethylene glycol) (PEG), named PEGylated nanocarriers, a type of combination therapy, is becoming an increasingly important method of long-term drug delivery, to decrease side effects, avoid multidrug resistance, and increase therapeutic efficacy. However, repeated injections of PEGylated nanocarriers induces the accelerated blood clearance (ABC) phenomenon, prevents long circulation, and can cause adverse effects owing to alterations in the biodistribution of the drug. Although the nature of the ABC phenomenon that is induced by repeated injections of PEGylated nanocarriers has already been studied in detail, there are few reports on the immune response elicited by the cross-administration of PEGylated nanocarriers. In this study, we investigated the ABC phenomenon induced by the intravenous cross-administration of various PEGylated nanocarriers, including PEGylated liposomes (PL), PEG micelles (PM), PEGylated solid lipid nanoparticles (PSLN), and PEGylated emulsions (PE), in beagle dogs. The results indicated that the magnitude of the immune response elicited by the cross-administration was in the following order (from the strongest to the weakest): PL, PE, PSLN, PM. It is specifically PEG in the brush structure that elicits a significant immune response, in both the induction phase and the effectuation phase. Furthermore, the present study suggests that there is a considerable difference between the effect of repeated injections and cross-administration, depending on the colloidal structure. This work is a preliminary investigation into the cross-administration of PEGylated nanocarriers, and our observations can have serious implications for the design of combination therapies that use PEGylated vectors.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 27%
Researcher 4 15%
Student > Bachelor 4 15%
Student > Ph. D. Student 3 12%
Student > Doctoral Student 2 8%
Other 3 12%
Unknown 3 12%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 8 31%
Agricultural and Biological Sciences 4 15%
Chemistry 4 15%
Medicine and Dentistry 3 12%
Social Sciences 1 4%
Other 3 12%
Unknown 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2015.
All research outputs
#1,892,490
of 5,099,351 outputs
Outputs from International Journal of Nanomedicine
#147
of 1,344 outputs
Outputs of similar age
#59,021
of 163,925 outputs
Outputs of similar age from International Journal of Nanomedicine
#3
of 56 outputs
Altmetric has tracked 5,099,351 research outputs across all sources so far. This one has received more attention than most of these and is in the 62nd percentile.
So far Altmetric has tracked 1,344 research outputs from this source. They receive a mean Attention Score of 1.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,925 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.