| Title |
Amalgamation of complex iron(III) ions and iron nanoclusters with MWCNTs as a route to potential T2 MRI contrast agents
|
|---|---|
| Published in |
International Journal of Nanomedicine, May 2015
|
| DOI | 10.2147/ijn.s81381 |
| Pubmed ID | |
| Authors |
Nikodem Kuźnik, Mateusz M Tomczyk, Marzena Wyskocka, Łukasz Przypis, Artur P Herman, Rafał Jędrysiak, Krzysztof K Koziol, Sławomir Boncel |
| Abstract |
Iron-filled multiwall carbon nanotubes (Fe@MWCNTs) were functionalized toward a variety of potential magnetic resonance imaging contrast agents. Oxidized Fe@MWNCTs were covered with PEG5000 via direct esterification or using acyl chloride derivatives. Alternatively, the latter were functionalized with an aminophenol ligand (Fe@O-MWCNT-L). Moreover, pristine Fe@MWCNTs were functionalized with N-phenylaziridine groups (Fe@f-MWCNT) via [2+1] cycloaddition of nitrene. All of these chemically modified nanotubes served as a vehicle for anchoring Fe(3+) ions. The new hybrids - Fe(III)/Fe@(f-/O-)MWCNTs - containing 6%-14% of the "tethered" Fe(3+)ions were studied in terms of the acceleration of relaxation of water protons in nuclear magnetic resonance. The highest transverse relaxivity r 2=63.9±0.9 mL mg(-1) s(-1) was recorded for Fe(III)/Fe@O-MWCNT-L, while for Fe(III)/Fe@f-MWCNT, with r 2=57.9±2.9 mL mg(-1) s(-1), the highest impact of the anchored Fe(III) ions was observed. The T 1/T 2 ratio of 30-100 found for all of the nanotube hybrids presented in this work is a very important factor for their potential application as T 2 contrast agents. Increased stability of the hybrids was confirmed by ultraviolet-visible spectrophotometry. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 19% |
| Professor | 3 | 14% |
| Researcher | 3 | 14% |
| Student > Ph. D. Student | 3 | 14% |
| Student > Bachelor | 2 | 10% |
| Other | 4 | 19% |
| Unknown | 2 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 10 | 48% |
| Materials Science | 2 | 10% |
| Physics and Astronomy | 2 | 10% |
| Unspecified | 1 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 3 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2015.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from International Journal of Nanomedicine
#2,470
of 4,123 outputs
Outputs of similar age
#168,907
of 278,920 outputs
Outputs of similar age from International Journal of Nanomedicine
#64
of 89 outputs
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