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Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery

Overview of attention for article published in International Journal of Nanomedicine, March 2015
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Title
Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery
Published in
International Journal of Nanomedicine, March 2015
DOI 10.2147/ijn.s77667
Pubmed ID
Authors

Dunwan Zhu, Linhua Zhang, Xia Dong, Hongfan Sun, Cunxian Song, Chun Wang, Deling Kong

Abstract

The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a poly(ε-caprolactone) hydrophobic core based on self-assembly of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) amphiphilic copolymers, 2) a lipid monolayer formed with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000] (DSPE-PEG2000), 3) a targeting ligand (FA) on the surface, and were prepared using a thin-film hydration and ultrasonic dispersion method. Transmission electron microscopy and dynamic light scattering analysis confirmed the coating of the lipid monolayer on the hydrophobic polymer core. Physicochemical characterizations of PTX-loaded FLPNPs, such as particle size and size distribution, zeta potential, morphology, drug loading content, encapsulation efficiency, and in vitro drug release, were also evaluated. Fluorescent microscopy proved the internalization efficiency and targeting ability of the folate conjugated on the lipid monolayer for the EMT6 cancer cells which overexpress folate receptor. In vitro cytotoxicity assay demonstrated that the cytotoxic effect of PTX-loaded FLPNPs was lower than that of Taxol(®), but higher than that of PTX-loaded LPNPs (without folate conjugation). In EMT6 breast tumor model, intratumoral administration of PTX-loaded FLPNPs showed similar antitumor efficacy but low toxicity compared to Taxol(®). More importantly, PTX-loaded FLPNPs showed greater tumor growth inhibition (65.78%) than the nontargeted PTX-loaded LPNPs (48.38%) (P<0.05). These findings indicated that the PTX loaded-FLPNPs with mixed lipid monolayer shell and biodegradable polymer core would be a promising nanosized drug formulation for tumor-targeted therapy.

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 3%
United Kingdom 1 1%
Brazil 1 1%
Unknown 63 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Student > Master 13 19%
Student > Bachelor 6 9%
Student > Doctoral Student 4 6%
Lecturer 4 6%
Other 14 21%
Unknown 9 13%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 17 25%
Medicine and Dentistry 10 15%
Materials Science 5 7%
Engineering 5 7%
Biochemistry, Genetics and Molecular Biology 4 6%
Other 15 22%
Unknown 11 16%